保留卵巢对宫颈鳞癌患者术后卵巢功能、骨质丢失以及性生活的影响分析

发布时间：2018-12-05 20:02

【摘要】：目的:观察保留卵巢与切除卵巢对宫颈鳞癌患者术后卵巢功能、骨质丢失以及性生活的影响。方法:临床纳入宫颈鳞癌手术患者72例,根据术中卵巢的保留情况分为研究组与对照组。研究组保留单侧或双侧卵巢,对照组切除双侧卵巢。观察两组患者术后激素水平(雌二醇、促卵泡素、促黄体生成素等)、骨质丢失情况、性生活情况、精神心理状态等。结果:研究组术后3个月雌二醇、促卵泡素、促黄体生成素水平为(97.0±16.1)pmol/L、(8.3±0.9)IU/L、(7.1±0.7)IU/L,对照组分别为(34.7±5.2)pmol/L、(86.3±7.2)IU/L、(51.1±3.0)IU/L,差异具有显著性(P0.05);研究组术后6个月雌二醇、促卵泡素、促黄体生成素水平为(114.2±20.2)pmol/L、(9.3±0.6)IU/L、(8.5±0.2)IU/L,对照组分别为(41.3±3.9)pmol/L、(76.5±8.0)IU/L、(46.7±2.5)IU/L,差异均有显著性(P0.05);研究组术后3个月、6个月骨质丢失率为0.46%、0.72%,对照组分别为4.08%、5.23%,差异均有显著性(P0.05);研究组术后3个月、6个月性生活恢复率分别为16.67%、38.89%,对照组分别为2.78%、16.67%,差异均有显著性(P0.05);研究组术后3个月、6个月抑郁量表总分分别为(49.5±13.9)、(39.2±15.5),对照组分别为(57.4±15.4)、(51.4±13.0),差异均有显著性(P0.05)。结论:术中保留卵巢能够有效避免宫颈鳞癌患者术后雌激素水平的降低,从而防止骨质丢失以及性激素缺乏。此外,还能够改善患者的性生活,提高生活质量。
[Abstract]:Aim: to observe the effects of ovariectomy and ovariectomy on ovarian function, bone loss and sex life in patients with squamous cell carcinoma of the cervix. Methods: 72 patients with cervical squamous cell carcinoma were divided into study group and control group. The study group had one or two ovaries, while the control group had both ovariectomies. The levels of hormone (estradiol, follicle stimulating hormone, luteinizing hormone, etc.), bone loss, sexual life, mental and psychological status were observed. Results: the levels of estradiol, follicle stimulating hormone and luteinizing hormone were (97.0 卤16.1) pmol/L, (8.3 卤0.9) IU/L, and (7.1 卤0.7) IU/L, in study group 3 months after operation. The control group (34.7 卤5.2) pmol/L, (86.3 卤7.2) IU/L, (51.1 卤3.0) IU/L, had significant difference (P0.05). The levels of estradiol, follicle stimulating hormone and luteinizing hormone were (114.2 卤20. 2) pmol/L, (9. 3 卤0. 6) IU/L, and (8. 5 卤0. 2) IU/L, in the study group 6 months after operation, respectively, and were (41. 3 卤3. 9) pmol/L, in the control group. (76.5 卤8.0) IU/L, (46.7 卤2.5) IU/L, were significantly different (P0.05). In the study group, the bone loss rate was 0.46 and 0.72 at 3 months and 6 months after operation, respectively, while in the control group it was 4.08 and 5.23.The difference was significant (P0.05). The recovery rate of sexual life in the study group at 3 months and 6 months after operation was 16.67 and 38.89, respectively, while that in the control group was 2.78 and 16.67, respectively, with significant difference (P0.05). The total scores of depression scale were (49.5 卤13.9), (, 39.2 卤15.5) in the study group and (57.4 卤15.4), (, 51.4 卤13.0) in the control group, respectively. The difference was significant (P0.05). Conclusion: preservation of ovary during operation can effectively avoid the decrease of estrogen level and prevent bone loss and sex hormone deficiency in patients with squamous cell carcinoma of the cervix. In addition, can also improve the patient's sexual life, improve the quality of life.
【作者单位】：华北石油井下医院妇产科;华北石油管理局总医院妇产科;华北石油管理局总医院普外科;华北石油管理局总医院神经内科;
【分类号】：R737.33

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