体外受精-胚胎移植后异位妊娠86例临床分析

发布时间：2018-12-09 15:36

【摘要】：目的探讨辅助生殖技术中异位妊娠(EP)的发生率、影响因素和早期诊疗、防治的方法。方法回顾性分析体外受精-胚胎移植(IVF-ET)、卵胞浆内单精子显微注射(ICSI)、胚胎植入前遗传学诊断(PGD)和冻融胚胎移植(FET)治疗后86例EP患者的临床资料。结果共有2 903个周期获临床妊娠,86例EP,发生率2.96%,其中包括宫内宫外同时妊娠4例(4.65%)。患者年龄、不孕年限、体重指数、是否合并排卵障碍、男方因素不孕、染色体异常、既往分娩史、获卵数、移植胚胎数目、移植管进入宫腔深度对EP的发生影响不大。输卵管盆腔病变、子宫内膜异位症及其术后与EP的发生有显著的关联(OR=11.457,P=0.000;OR=3.479,P=0.002)。子宫内膜厚度≥7.5 mm时,输卵管妊娠风险则有所下降(OR=10.463,P=0.002)。结论输卵管盆腔病变,子宫内膜异位症及其术后,移植日子宫内膜厚度是EP发生的重要影响因素。妊娠早期血人绒毛膜促性腺激素(HCG)监测结合阴道B超检查是EP主要的早期诊断方法。
[Abstract]:Objective to investigate the incidence, influencing factors, early diagnosis and treatment, prevention and treatment of ectopic pregnancy (EP) in assisted reproductive technology. Methods the clinical data of 86 patients with EP after in vitro fertilization and embryo transfer (IVF-ET), intracytoplasmic sperm microinjection (ICSI), embryo implantation genetics and frozen and thawed embryo transfer (FET) were analyzed retrospectively. Results there were 2 903 cycles of clinical pregnancy, 86 cases of EP, occurred 2.96%, including 4 cases of intrauterine pregnancy (4.65%). Age, length of infertility, body mass index (BMI), male factor infertility, chromosome abnormality, previous delivery history, number of eggs acquired, number of embryos transferred, depth of transfer tube into uterine cavity had little effect on the occurrence of EP. Fallopian tube pelvic lesions, endometriosis and postoperative EP have a significant correlation (OR=11.457,P=0.000;OR=3.479,P=0.002). The risk of tubal pregnancy decreased with endometrial thickness 鈮，

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