蜕膜NK细胞与不明原因复发性流产关系的研究进展

发布时间：2018-12-12 00:56

【摘要】：蜕膜自然杀伤(d NK)细胞是妊娠时聚集在母胎界面的蜕膜组织中的NK细胞,是妊娠早期蜕膜组织主要的淋巴细胞。该群NK细胞具有促进滋养层细胞侵袭、促血管生成以及促进免疫耐受等功能;而它们的功能异常直接影响妊娠的发展,是导致复发性流产发生的原因之一。对蜕膜NK细胞功能和其上游或下游调控分子的研究将为复发性流产治疗提供新的思路。本文总结了蜕膜NK细胞的特征、功能、对妊娠的影响以及与复发性流产的关系。
[Abstract]:Decidua natural killer (d NK) cells are NK cells in decidua tissue gathered at the maternal and fetal interface during pregnancy, and are the main lymphocytes in decidua tissue in early pregnancy. The NK cells have the functions of promoting trophoblastic cell invasion, angiogenesis and immune tolerance, and their abnormal function directly affects the development of pregnancy, which is one of the causes of recurrent abortion. The study of decidual NK cell function and its upstream or downstream regulatory molecules will provide new ideas for the treatment of recurrent abortion. This paper summarizes the characteristics, functions, effects of decidual NK cells on pregnancy and its relationship with recurrent abortion.
【作者单位】：第四军医大学唐都医院妇产科;第四军医大学基础部免疫学教研室;
【基金】：国家自然科学基金(81370710)
【分类号】：R714.21

【相似文献】