子宫内膜搔刮术在反复移植失败患者中的临床应用

发布时间：2018-12-13 03:39

【摘要】：目的探讨子宫内膜搔刮术在反复移植失败(repeated implantation failure,RIF)患者中的临床应用价值。方法选择2013年10月至2014年8月在华中科技大学同济医学院附属同济医院生殖中心就诊,因女方输卵管因素不孕(男方精液正常)行IVF-ET治疗反复移植失败再次进入新的IVF-ET周期的患者,进行前瞻性随机对照研究。按病例编号把纳入标准的189例患者随机分成实验组(n=96)和对照组(n=93),实验组在取卵周期前1个月经周期月经来潮6h内进行内膜搔刮,对照组不行内膜搔刮,比较胚胎移植后两组临床结局。结果两组患者年龄、不孕年限、体重指数、基础血清FSH、LH及P水平、Gn天数、Gn总量、获卵数、胚胎移植数、HCG日血清E2、P水平及HCG日内膜厚度相比较,差异均无统计学意义(均P0.05),实验组胚胎着床率、临床妊娠率及持续妊娠率均明显高于对照组,差异均有统计学意义(均P0.01)。结论子宫内膜搔刮术可以改善子宫内膜容受性,提高RIF患者的临床妊娠率。
[Abstract]:Objective to evaluate the clinical value of endometrial curettage in (repeated implantation failure,RIF patients. Methods from October 2013 to August 2014, we selected the reproductive center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. A prospective randomized controlled study was conducted in women with infertility due to fallopian tube factor (normal semen of the male) who failed to enter the new IVF-ET cycle after repeated transplantation with IVF-ET. According to the case number, 189 patients were randomly divided into two groups: experimental group (n = 96) and control group (n = 93). To compare the clinical outcomes of the two groups after embryo transfer. Results Age, infertile age, body mass index, basal serum FSH,LH and P levels, days of Gn, total Gn, number of eggs acquired, number of embryo transfer, serum E2P level on HCG day and intimal thickness of HCG were compared between the two groups. There was no significant difference (P0.05). The embryo implantation rate, clinical pregnancy rate and continuous pregnancy rate in the experimental group were significantly higher than those in the control group (P0.01). Conclusion endometrial curettage can improve endometrial receptivity and improve the clinical pregnancy rate of RIF patients.
【作者单位】：华中科技大学同济医学院附属同济医院生殖中心;
【分类号】：R714.8

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