盆腔炎与卵巢肿瘤发生风险的Meta分析

发布时间：2018-12-13 04:41

【摘要】：目的 Meta分析盆腔炎性疾病(pelvic inflammatory disease,PID)与卵巢肿瘤发病风险的相关性。方法采用Cochrane系统评价方法,检索Pub Med、EMbase、Cochrane Library、中国生物医学文献数据库、中国知网和万方数据库的队列研究及病例-对照研究相关文献。采用Rev Man 5.2软件进行统计分析,分别计算纳入队列研究和病例-对照研究的合并优势比(OR)及其95%CI。结果共纳入2个队列研究和8个病例-对照研究。队列研究Meta分析结果显示,PID暴露可增加卵巢肿瘤的发生风险(OR=1.72,95%CI:1.17~2.52,P=0.006);病例-对照研究Meta分析结果显示,PID暴露史并未明显增加卵巢肿瘤的发生风险(OR=1.07,95%CI:0.86~1.33,P=0.55)。但有2个研究发现复发性PID可增加卵巢肿瘤的发病风险。结论队列研究与病例-对照研究的Meta分析结论相矛盾;但有关复发性PID的研究均提示随着PID暴露次数增多卵巢癌的风险也随之增加。鉴于病例-对照研究自身缺陷及队列研究较少,尚需开展更多高质量的前瞻性研究以进一步验证上述结果,尤其是有关复发性或慢性PID与卵巢肿瘤的风险关系。
[Abstract]:Objective to analyze the correlation between (pelvic inflammatory disease,PID (pelvic inflammatory disease) and ovarian tumor risk by Meta. Methods the cohort study and case-control study of Pub Med,EMbase,Cochrane Library, Chinese Biomedical Literature Database, China knowledge Network and Wanfang Database were searched by Cochrane system evaluation method. The combined advantage ratio of (OR) and 95 CIs in cohort study and case-control study were calculated by Rev Man 5.2 software. Results two cohort studies and eight case-control studies were included. Cohort study Meta analysis showed that PID exposure increased the risk of ovarian neoplasms (OR=1.72,95%CI:1.17~2.52,P=0.006). Case-control study Meta analysis showed that PID exposure history did not significantly increase the risk of ovarian neoplasms (OR=1.07,95%CI:0.86~1.33,P=0.55). However, two studies have found that recurrent PID increases the risk of ovarian tumors. Conclusion the cohort study is inconsistent with the Meta analysis of the case-control study, but the studies on recurrent PID suggest that the risk of ovarian cancer increases with the increase of PID exposure. In view of the lack of self-defect and cohort studies in case-control studies, more high-quality prospective studies are needed to further verify these findings, especially in relation to recurrent or chronic PID and the risk of ovarian tumors.
【作者单位】：兰州大学第一临床医学院;兰州大学第一医院妇产科;
【基金】：甘肃省循证医学与临床转化重点实验室(开放基金)
【分类号】：R737.31

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