甲状腺功能减退对血糖水平及妊娠结局的影响

发布时间：2018-12-13 15:47

【摘要】：目的:分析甲状腺功能减退孕妇的血糖变化,以及甲状腺功能减退症对妊娠结局的影响。方法:选取2014年1月1日—12月31日在本院定期产检并分娩的孕产妇1 000例进行甲状腺功能及糖耐量检测,测定其血液促甲状激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平,筛查出甲减孕妇121例,并对TSH及血糖水平进行相关性分析,追踪其妊娠结局,选取同期甲功正常的孕产妇100例作为对照组。结果:孕妇中妊娠合并甲状腺功能减退121例,发病率为12.1%,血糖水平较甲功正常孕妇的血糖水平明显增高(P0.05),其中空腹血糖与TSH有相关性(P0.05,r=0.39)。追踪妊娠结局:121例中有92例合并各类产科合并症及分娩期并发症,约占76.03%。甲减孕妇中妊娠期高血压、妊娠期糖尿病、胎儿窘迫、胎儿生长受限等并发症较甲功正常的孕妇发病率高。结论:妊娠合并甲减的发生率高,对母儿的不利影响较大,应对甲减孕妇加强血糖监测,及孕期、分娩期合并症的监测及处理。
[Abstract]:Aim: to analyze the changes of blood glucose in pregnant women with hypothyroidism and the effect of hypothyroidism on pregnancy outcome. Methods: from January 1 to December 31, 2014, 1 000 pregnant and parturient women in our hospital were tested for thyroid function and glucose tolerance, and their blood thyrotropin (TSH),) free triiodothyronine (FT3) was determined. The levels of free thyroxine (FT4) were screened out in 121 pregnant women with hypothyroidism. The TSH and blood glucose levels were analyzed to track the pregnancy outcome. 100 pregnant women with normal hypothyroidism were selected as the control group. Results: among the 121 pregnant women with hypothyroidism, the incidence of hypothyroidism was 12.1.The level of blood glucose was significantly higher than that of normal pregnant women (P0.05), and there was a correlation between fasting blood glucose and TSH (P0.05r.39). Follow-up pregnancy outcome: 92 of 121 cases (76.03) were complicated with all kinds of obstetric complications and parturition complications. The incidence of complications such as gestational hypertension gestational diabetes fetal distress and fetal growth restriction in hypothyroidism women is higher than that in normal pregnant women. Conclusion: the incidence of pregnancy complicated with hypothyroidism is high and the adverse effect on mother and infant is great. The pregnant women with hypothyroidism should strengthen the monitoring of blood sugar and monitor and deal with complications during pregnancy and delivery.
【作者单位】：苏州市吴江区第一人民医院产科;
【基金】：苏州市吴江区科技局立项(WS201303)
【分类号】：R714.256

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