沧州地区妊娠妇女甲状腺功能及参考值范围的初步研究

发布时间：2018-12-13 19:06

【摘要】：目的建立沧州地区妊娠妇女妊娠期甲状腺功能及参考值范围,为本地区筛查和监测孕妇甲状腺功能异常提供依据。方法于2013年8月至2014年12月选取正常妊娠妇女647例作为研究组,由于甲状腺功能参考值具有孕龄特异性,故按孕周分为孕早期(1~12周)、孕中期(13~27周)、孕晚期(28~40周)三组,另选取健康非孕妇女174例作为对照组,采用电化学免疫分析法测定其血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)水平。结果妊娠妇女血清TSH水平在孕早期、孕中期低于对照组,差异均有统计学意义(P0.05);血清FT_3、FT_4水平变化相似,孕早期、孕中期、孕晚期均低于对照组,孕早期高于孕中期,孕中期高于孕晚期,差异均有统计学意义(P0.05)。结论妊娠期妇女甲状腺激素水平随妊娠期不同发生相应改变,孕早期血清TSH较低,FT_3、FT_4较高。
[Abstract]:Objective to establish the range of thyroid function and reference value of pregnant women in Cangzhou area, and to provide evidence for screening and monitoring abnormal thyroid function of pregnant women. Methods from August 2013 to December 2014, 647 normal pregnant women were selected as the study group. Because the reference value of thyroid function was specific to gestational age, it was divided into early pregnancy (1 ~ 12 weeks) and second trimester (13 ~ 27 weeks) according to gestational age. In the third trimester group (28 weeks 40 weeks), 174 healthy non-pregnant women were selected as control group. The serum thyroid stimulating hormone (TSH),) free triiodothyronine (FT_3) was determined by electrochemical immunoassay. Free thyroxine (FT_4) level. Results the serum TSH level of pregnant women was significantly lower than that of the control group in the early pregnancy and the second trimester of pregnancy (P0.05). The changes of serum FT_3,FT_4 level were similar. The levels of serum FT_3,FT_4 in early pregnancy, middle pregnancy and late pregnancy were lower than those in control group, higher in early pregnancy than in second trimester and higher in second trimester, the differences were statistically significant (P0.05). Conclusion the thyroid hormone level in pregnant women varies with the gestational period. The serum TSH is lower and FT_3,FT_4 is higher in early pregnancy.
【作者单位】：沧州市人民医院产科;沧州医学高等专科学校;
【基金】：沧州市科学技术研究与发展指导计划项目(151302073)
【分类号】：R714;R446.1

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