辅助生育技术及自然受孕双胎妊娠的围产期情况及新生儿结局:811例回顾性分析

发布时间：2018-12-15 02:31

【摘要】：目的探讨辅助生育技术受孕(助孕)双胎妊娠与自然受孕双胎妊娠孕妇的一般情况、妊娠期并发症、分娩情况及新生儿结局等。方法收集2015年1月1日-2016年12月31日在上海交通大学医学院附属国际和平妇幼保健院分娩的811例双胎妊娠孕妇的一般情况、孕期及分娩期资料和新生儿资料等,其中辅助生育技术受孕双胎妊娠孕妇(助孕组)518例,自然受孕双胎妊娠孕妇(自然受孕组)293例。对两组孕妇的基本情况、妊娠期并发症、分娩情况及新生儿结局进行回顾性分析。结果助孕组孕妇年龄大于自然受孕组(P0.05),但自然受孕组孕妇孕产次多于助孕组(P0.05);与自然受孕组比较,助孕组双受精卵及双绒毛膜性的比例较高(P0.05)。助孕组孕妇的妊娠期糖尿病发生率、胎盘异常(胎盘粘连、胎盘植入、前置胎盘)发生率及产后出血量均明显高于自然受孕组(P0.05),而妊娠期高血压疾病、妊娠期胆汁淤积症等妊娠期并发症发生率两组差异无统计学意义(P0.05)。两组双胎妊娠孕妇的新生儿出生体重、新生儿窒息率、先天畸形发生率及新生儿死亡发生率差异无统计学意义(P0.05)。结论助孕双胎妊娠孕妇的妊娠期糖尿病及胎盘异常发生率高,产后出血量多,但其新生儿结局与自然受孕双胎孕妇的新生儿结局无明显差异。
[Abstract]:Objective to investigate the general situation, complications, delivery and neonatal outcome of assisted fertility technique (assisted pregnancy) twin pregnancy and natural pregnancy twin pregnancy. Methods from January 1, 2015 to December 31, 2016, 811 pregnant women with twin pregnancies delivered at the International Peace Maternal and Child Health Institute, School of Medicine, Shanghai Jiaotong University, were collected. There were 518 cases of assisted pregnancy twin pregnancy (assisted pregnancy group) and 293 cases of natural conception twin pregnancy group (natural pregnancy group). The basic condition, pregnancy complications, delivery condition and neonatal outcome of the two groups were analyzed retrospectively. Results the pregnant women in the aid group were older than those in the natural conception group (P0.05), but the pregnant women in the natural pregnant group were more pregnant than those in the assisted pregnancy group (P0.05), and the proportion of double fertilized eggs and chorionic membrane in the aid group was higher than that in the natural pregnant group (P0.05). The incidence of gestational diabetes mellitus, placental abnormality (placenta adhesions, placenta accreta, placenta previa) and postpartum hemorrhage in pregnancy aid group were significantly higher than those in natural conception group (P0.05). The incidence of complications of pregnancy such as cholestasis of pregnancy was not significantly different between the two groups (P0.05). There was no significant difference in birth weight, neonatal asphyxia rate, congenital malformation rate and neonatal death rate between the two groups (P0.05). Conclusion the incidence of gestational diabetes mellitus and placental abnormality is high and the amount of postpartum hemorrhage is more in twin pregnancy, but there is no significant difference between the neonatal outcome of pregnant twin pregnancy and that of natural twin pregnancy.
【作者单位】：上海交通大学医学院附属国际和平妇幼保健院;
【分类号】：R714.8

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