SREBP1在宫颈癌发生发展中的作用研究

发布时间：2018-12-16 07:15

【摘要】：目的探讨固醇调节元件结合蛋白(SREBP1)在宫颈癌中的表达及其在宫颈癌发生发展中的作用及意义。方法宫颈标本共100例,采自2009年1月至2013年12月郑州人民医院妇科,包括宫颈癌组织50例,同期病理检查的宫颈非癌组织50例作为对照。采用实时定量聚合酶链反应(RT-PCR)检测宫颈癌组织及正常宫颈组织中SREBP1m RNA的表达。分析SREBP1的表达水平与宫颈癌标本的病理分级、临床分期等临床资料的相关性。结果 SREBP1m RNA在宫颈癌中的表达高于正常宫颈组织(0.60±0.18对0.13±0.04,P0.01)。SREBP1的表达在宫颈癌中与病理分级、临床分期有相关性(P0.05),与病人年龄、肿瘤大小及肿瘤分型无关(P0.05)。SREBP1调控内源性脂肪酸合成酶(FASN)表达,两者呈正相关关系(r=0.705,P0.05)。结论 SREBP1参与宫颈癌的发生发展,为寻找宫颈癌临床治疗的潜在靶点提供了一定的思路。
[Abstract]:Objective to investigate the expression of steroid regulatory element binding protein (SREBP1) in cervical carcinoma and its role in the carcinogenesis and development of cervical carcinoma. Methods A total of 100 cervical specimens were collected from Zhengzhou people's Hospital from January 2009 to December 2013, including 50 cases of cervical cancer tissues, and 50 cases of cervical non-cancerous tissues from the same period of pathological examination as control. Real-time quantitative polymerase chain reaction (RT-PCR) was used to detect the expression of SREBP1m RNA in cervical carcinoma and normal cervical tissues. To analyze the correlation between the expression of SREBP1 and the pathological grade, clinical stage and other clinical data of cervical cancer. Results the expression of SREBP1m RNA in cervical cancer was higher than that in normal cervix (0.60 卤0.18 vs 0.13 卤0.04 P 0.01). The expression of SREBP1 in cervical carcinoma was correlated with pathological grade and clinical stage (P0.05). There was no correlation between tumor size and tumor type (P0.05). The expression of endogenous fatty acid synthase (FASN) regulated by SREBP1 was positively correlated (r 0.705 P 0.05). Conclusion SREBP1 is involved in the occurrence and development of cervical cancer and provides some ideas for finding potential targets for clinical treatment of cervical cancer.
【作者单位】：郑州人民医院妇科;
【分类号】：R737.33

【共引文献】