血清CysC、β2-MG在妊娠期高血压疾病早期肾功能损伤中的意义
发布时间：2018-12-16 12:10
【摘要】：目的探讨血清胱抑素(CysC)及血清β2-微球蛋白(β2-MG)在评估妊娠期高血压疾病(HDCP)患者早期肾功能损伤中的临床价值。方法采用全自动生化分析仪检测108例HDCP患者(妊娠期高血压组41例,轻度子痫前期组30例,重度子痫前期组37例)及孕周相近的健康单胎妊娠妇女(对照组40例)血清中CysC、β2-MG、肌酐(Cr)的水平。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组患者血清CysC、β2-MG水平均显著高于对照组(P0.05);妊娠期高血压组、轻度子痫前期组、重度子痫前期组3组间血清CysC、β2-MG水平比较,差异均有统计学意义(妊娠期高血压组轻度子痫前期组重度子痫前期组,P0.05)。妊娠期高血压组、轻度子痫前期组和对照组之间血清Cr水平比较差异均无统计学意义(P0.05),而重度子痫前期组与对照组之间血清Cr水平差异有统计学意义(P0.05)。相关分析结果显示HDCP患者血清CysC与β2-MG、Cr呈正相关。结论联合检测血清CysC、β2-MG、Cr对判断HDCP孕妇病情严重程度及诊断早期肾功能损伤具有重要的临床价值。
[Abstract]:Objective to evaluate the clinical value of serum cystatin (CysC) and 尾 2 microglobulin (尾 2-MG) in evaluating early renal dysfunction in patients with hypertensive disorder complicating pregnancy (HDCP). Methods the serum CysC, of 108 patients with HDCP (41 patients with hypertension complicating pregnancy, 30 patients with mild preeclampsia and 37 patients with severe preeclampsia) and 40 healthy single pregnancy women with similar gestational age (control group) were detected by automatic biochemical analyzer. 尾 2 MG, creatinine (Cr) level. Results the serum levels of CysC, 尾 2-MG in hypertensive complicating pregnancy group, mild preeclampsia group and severe preeclampsia group were significantly higher than those in control group (P0.05). The levels of serum CysC, 尾 2-MG were significantly different among the three groups: gestational hypertension group, mild preeclampsia group and severe preeclampsia group (P0.05). There was no significant difference in serum Cr levels between the pregnant hypertension group, the mild preeclampsia group and the control group (P0.05), but there was significant difference in the serum Cr level between the severe preeclampsia group and the control group (P0.05). Correlation analysis showed that serum CysC was positively correlated with 尾 2-MGG Cr in patients with HDCP. Conclusion the combined detection of serum CysC, 尾 2-MGG Cr in pregnant women with HDCP has important clinical value in judging the severity of the disease and in diagnosing early renal function injury.
【作者单位】： 江苏省无锡市第三人民医院妇产科;
【基金】：江苏省自然科学基金(青年科学基金)项目(BK20140125)
【分类号】：R714.246
[Abstract]:Objective to evaluate the clinical value of serum cystatin (CysC) and 尾 2 microglobulin (尾 2-MG) in evaluating early renal dysfunction in patients with hypertensive disorder complicating pregnancy (HDCP). Methods the serum CysC, of 108 patients with HDCP (41 patients with hypertension complicating pregnancy, 30 patients with mild preeclampsia and 37 patients with severe preeclampsia) and 40 healthy single pregnancy women with similar gestational age (control group) were detected by automatic biochemical analyzer. 尾 2 MG, creatinine (Cr) level. Results the serum levels of CysC, 尾 2-MG in hypertensive complicating pregnancy group, mild preeclampsia group and severe preeclampsia group were significantly higher than those in control group (P0.05). The levels of serum CysC, 尾 2-MG were significantly different among the three groups: gestational hypertension group, mild preeclampsia group and severe preeclampsia group (P0.05). There was no significant difference in serum Cr levels between the pregnant hypertension group, the mild preeclampsia group and the control group (P0.05), but there was significant difference in the serum Cr level between the severe preeclampsia group and the control group (P0.05). Correlation analysis showed that serum CysC was positively correlated with 尾 2-MGG Cr in patients with HDCP. Conclusion the combined detection of serum CysC, 尾 2-MGG Cr in pregnant women with HDCP has important clinical value in judging the severity of the disease and in diagnosing early renal function injury.
【作者单位】： 江苏省无锡市第三人民医院妇产科;
【基金】：江苏省自然科学基金(青年科学基金)项目(BK20140125)
【分类号】：R714.246
【参考文献】
相关期刊论文 前9条
1 林一民;林丁;吴立翔;;血清β_2-微球蛋白对肾功能的预测价值[J];重庆医学;2009年20期
2 单虹;;子痫前期患者血清β_2-微球蛋白的变化及其临床意义[J];海南医学;2013年07期
3 卢卫国;何静;;血清胱抑素C对早期肾功能损伤诊断价值分析[J];检验医学与临床;2013年12期
4 宋清玲;;血清β_2-微球蛋白在妊娠高血压综合征早期肾功能诊断中的意义[J];检验医学与临床;2014年05期
5 黄启涛;高云飞;王艳;靳瑾;冷灵芝;肖超群;钟梅;;血清胱抑素C水平与早发型子痫前期发生和不良妊娠结局关系探讨[J];实用妇产科杂志;2012年04期
6 罗红权;陈新敏;薛峰;;妊娠高血压综合征患者血清胱抑素C检测的临床应用[J];实用医学杂志;2010年10期
7 钱宇佳;贾瑞U，
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