子宫内膜癌高危因素对淋巴结切除临床决策的指导意义
发布时间:2018-12-16 22:56
【摘要】:目的Ⅰ期子宫内膜癌手术范围是否应常规包括淋巴结切除国内外专家意见尚未统一。本研对临床Ⅰ期子宫内膜癌高危因素手术前后的诊断符合率进行分析,探讨临床Ⅰ期子宫内膜癌行淋巴结切除的指征。方法回顾性分析2010-05-10-2013-05-10青岛市立医院收治的127例Ⅰ期子宫内膜癌患者临床资料,所有患者均行腹腔镜下筋膜外全子宫+双附件切除+盆腔淋巴结清除术(其中55例同时行腹主动脉旁淋巴结清除术)。比较手术前后组织学分级、病理类型、肌层浸润深度和淋巴结转移的诊断符合情况,分析其与淋巴结转移的相关性。结果手术前后组织学分级诊断符合率为76.4%(97/127),8.1%(9/111)的患者新增为高危因素合并者;病理类型诊断符合率为89.8%(114/127),10.2%(13/127)的患者新增为高危因素合并者;肌层浸润诊断符合率为74.8%(95/127),20.4%(20/98)的患者新增为高危因素合并者;淋巴转移诊断符合率为89.0%(113/127),11.0%(14/127)的患者新增为高危因素合并者。14例淋巴结有转移,其中盆腔淋巴结转移10例,腹主动脉旁淋巴结转移1例,盆腔及腹主动脉旁淋巴结共同转移3例。2例术后病理确诊侵犯宫颈间质,其中1例伴有盆腔淋巴结转移。11.8%(15/127)的患者术后手术病理分期升高。淋巴结转移与组织学分级相关,χ~2=8.444,P=0.015;与肌层浸润相关,χ~2=7.601,P=0.004;而与病理类型无关,χ~2=0.995,P=0.156。病理确诊的低危患者(中、高分化子宫内膜样腺癌且肌层浸润1/2)淋巴结转移率为2.7%(2/75)。结论子宫内膜癌高危因素术前判断准确性不高,低危患者也可发生淋巴结转移,因此主张对临床Ⅰ期子宫内膜癌患者行全面的分期手术,更好地指导术后辅助治疗方案选择,从而改善患者预后。
[Abstract]:Objective whether the operative scope of stage I endometrial carcinoma should include lymphadenectomy is not uniform at home and abroad. This study analyzed the diagnostic coincidence rate before and after surgery for clinical stage I endometrial carcinoma, and discussed the indications of lymph node resection for clinical stage 鈪,
本文编号:2383184
[Abstract]:Objective whether the operative scope of stage I endometrial carcinoma should include lymphadenectomy is not uniform at home and abroad. This study analyzed the diagnostic coincidence rate before and after surgery for clinical stage I endometrial carcinoma, and discussed the indications of lymph node resection for clinical stage 鈪,
本文编号:2383184
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