硝苯地平联合酚妥拉明及硫酸镁治疗妊娠高血压疾病的临床疗效

发布时间：2018-12-16 23:04

【摘要】：目的探究硝苯地平联合酚妥拉明及硫酸镁的临床疗效。方法选取2010年8月至2015年1月在邢台市第三医院治疗的妊娠高血压疾病的孕妇共140例,根据随机数字表法分为联合治疗组、硫酸镁+酚妥拉明组、硫酸镁+硝苯地平组、酚妥拉明+硝苯地平组,各35例。联合治疗组采用硝苯地平+酚妥拉明+硫酸镁治疗,口服硝苯地平,每次10 mg,每日3次,静脉滴注酚妥拉明5 mg和硫酸镁4 g,以1周为1个疗程。硫酸镁+酚妥拉明组、硫酸镁+硝苯地平组、酚妥拉明+硝苯地平组用药方法同联合治疗组。记录4组患者治疗前后的收缩压与舒张压,观察治疗后的临床疗效。结果治疗后,联合治疗组血压低于硫酸镁+酚妥拉明组、硫酸镁+硝苯地平组、酚妥拉明+硝苯地平组[收缩压(112±8)mm Hg(1 mm Hg=0.133 k Pa)比(134±8)mm Hg、(132±10)mm Hg、(135±9)mm Hg,舒张压(68±5)mm Hg比(87±8)mm Hg、(83±7)mm Hg、(77±6)mm Hg,P0.05]。联合治疗组总有效率高于硫酸镁+酚妥拉明组、硫酸镁+硝苯地平组、酚妥拉明+硝苯地平组[100%(35/35)比77.1%(27/35)、82.8%(29/35)、74.3%(26/35)],差异有统计学意义(P0.05)。结论对于患有妊娠高血压疾病的孕妇,应用硝苯地平联合酚妥拉明及硫酸镁治疗能够达到更好的效果,值得更多的探索与应用。
[Abstract]:Objective to investigate the clinical effect of nifedipine combined with phentoLemine and magnesium sulfate. Methods A total of 140 pregnant women with pregnancy-induced hypertension treated in the third Hospital of Xingtai City from August 2010 to January 2015 were randomly divided into three groups: combined treatment group, magnesium sulfate phenolic Lemine group, and magnesium sulfate nifedipine group. Phentoid Lemine nifedipine group, 35 cases each. The combined treatment group was treated with nifedipine phenolic Lemine magnesium sulfate oral nifedipine 3 times a day for 10 mg, intravenous drip of phenolic Lemine 5 mg and magnesium sulfate 4 g for 1 week as a course of treatment. Magnesium sulfate phenolic Lemine group, magnesium sulfate nifedipine group, phenolic Lemine nifedipine group and combined treatment group. Systolic and diastolic blood pressure were recorded before and after treatment in 4 groups. Results after treatment, the blood pressure of the combined treatment group was lower than that of the magnesium sulfate phenolic Lemine group, the magnesium sulfate nifedipine group and the phentol Lemine nifedipine group [systolic pressure (112 卤8) mm Hg (1 mm Hg=0.133 k Pa) vs (134 卤8) mm Hg, (132 卤10) mm Hg,)] Diastolic blood pressure (DBP) was (135 卤9) mm Hg,) mm Hg (68 卤5) mm Hg) vs (87 卤8) mm Hg, (83 卤7) mm Hg, (77 卤6 mm Hg,P0.05). The total effective rate of the combined treatment group was higher than that of the magnesium phentol Lemine group, the magnesium sulfate nifedipine group and the phenolic Lemine nifedipine group [100% (35 / 35) vs 77.1% (27 / 35), 82.8% (29 / 35), 74.3% (26 / 35), the difference was statistically significant (P0.05). Conclusion for pregnant women with pregnancy-induced hypertension, nifedipine combined with phentoLemine and magnesium sulfate can achieve better results, which is worthy of more exploration and application.
【作者单位】：邢台市第三医院产一科;
【分类号】：R714.246

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