高强度聚焦超声及其联合甲氨蝶呤治疗剖宫产瘢痕妊娠疗效对比

发布时间：2018-12-19 11:17

【摘要】：目的比较高强度聚焦超声(HIFU)、甲氨蝶呤(MTX)联合高强度聚焦超声(MTX+HIFU)治疗剖宫产瘢痕妊娠的临床疗效。方法将40例诊断明确的子宫下段瘢痕妊娠(CSP)患者分为两组:HIFU组20例行HIFU治疗,MTX+HIFU组20例行MTX 50mg,第1、3天连续肌肉注后再行HIFU治疗,比较两组患者治疗后血β-HCG水平变化情况、清宫时阴道出血量,平均住院时间、月经恢复正常时间、超声提示术后子宫恢复情况,并进行随访。结果两组患者疗效比较,差异无统计学意义(P0.05),治疗后血β-HCG恢复时间、阴道出血量、平均住院天数、月经恢复正常时间方面比较差异有统计学意义(P0.05),其中,HIFU组血β-HCG恢复时间长、平均住院时间短、阴道出血量较多,MTX+HIFU组血β-HCG恢复时间短、平均住院时间稍长、阴道出血量少。两组患者均无严重不良反应发生。结论 HIFU联合MTX治疗CSP的疗效优于HIFU治疗。
[Abstract]:Objective to compare the clinical effect of high intensity focused ultrasound (HIFU) (HIFU), methotrexate (MTX) combined with high intensity focused ultrasound (MTX HIFU) in the treatment of cesarean scar pregnancy. Methods 40 patients with (CSP) of lower uterine scar pregnancy were divided into two groups: HIFU group (20 cases) were treated with HIFU and, MTX HIFU group (20 cases) were treated with MTX 50 mg, and then treated with HIFU after 3 days of continuous intramuscular injection. The changes of serum 尾-HCG, vaginal bleeding, average hospitalization time, menstrual recovery time and uterine recovery after operation were compared between the two groups. Results there was no significant difference in the curative effect between the two groups (P0.05). There were significant differences in the recovery time of serum 尾-HCG, vaginal bleeding volume, average hospitalization days, menstrual recovery time after treatment (P0.05). Among them, the recovery time of blood 尾-HCG in HIFU group was long, the average hospitalization time was short, the recovery time of blood 尾-HCG in HIFU group was shorter than that in, MTX HIFU group, the average hospitalization time was a little longer, and the amount of vaginal bleeding was less. No serious adverse reactions occurred in both groups. Conclusion HIFU combined with MTX is superior to HIFU in the treatment of CSP.
【作者单位】：四川省遂宁市中心医院妇产科;重庆医科大学生物医学工程学院;
【分类号】：R714.2

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