子宫内膜病变患者代谢异常的发病情况

发布时间：2018-12-27 11:56

【摘要】：目的探讨子宫内膜病变患者代谢综合征(MS)及其组分的发病情况,并与健康体检人群比较。方法选取妇科肿瘤专科进行初始治疗的子宫内膜病变患者517例(子宫内膜病变组),年龄匹配的同期体检女性517例为对照组,进行回顾性分析。MS的诊断采用2005年国际糖尿病联盟制定的标准。结果子宫内膜病变组和对照组MS比例分别为37.72%和7.74%;子宫内膜病变组的腰围、收缩压、舒张压、三酰甘油(TG)、空腹血糖(FPG)、体质指数水平均高于对照组;子宫内膜病变组代谢异常的比例从高到低分别为腰围大于18 cm、血脂异常、血压升高、FPG升高。对照组代谢异常比例的顺序与子宫内膜病变组相同。子宫内膜病变组合并MS 0~5个组分的比例分别为7.93%、18.76%、29.98%、25.73%、13.15%和4.45%;对照组分别为56.86%、28.43%、18.38%、5.80%、3.48%和0.77%。多因素分析显示,随着年龄,腰围、舒张压、TG增加,子宫内膜病变合并MS的风险增加;其中,TG与MS关系最为密切。结论子宫内膜病变与MS及其组分关系密切,控制代谢异常可能是预防子宫内膜病变及改善预后的一条新途径。
[Abstract]:Objective to investigate the incidence of metabolic syndrome (MS) and its components in patients with endometrial lesions, and to compare them with healthy subjects. Methods 517 patients with endometrial lesions (endometriosis group) and 517 age-matched women who underwent initial treatment were selected as control group. Retrospective analysis. The diagnosis of MS was based on the criteria set by the 2005 International Diabetes Federation. Results the percentage of MS in endometriosis group and control group were 37.72% and 7.74 respectively. The body mass index (BMI) of waist circumference, systolic blood pressure, diastolic blood pressure and triglyceride (TG), fasting blood glucose (FPG), in endometriosis group were higher than those in control group. The proportion of abnormal metabolism in endometriosis group from high to low were waist circumference > 18 cm, dyslipidemia, blood pressure rise and FPG increase. The order of metabolic abnormalities in the control group was the same as that in the endometriosis group. The ratio of 0 ~ 5 components of endometrial lesion combined with MS was 7.93% and 18.76%, 29.98% and 13.15% and 4.45%, respectively. In the control group, 56.86, 28.43 and 18.38 were 3.48% and 0.77%, respectively. Multivariate analysis showed that with age, waist circumference, diastolic blood pressure and TG increased, the risk of endometrial lesions complicated with MS was increased, among which TG and MS were the most closely related. Conclusion there is a close relationship between endometrial lesions and MS and its components. Controlling abnormal metabolism may be a new way to prevent endometrial lesions and improve prognosis.
【作者单位】：中山大学孙逸仙纪念医院妇科肿瘤专科;
【基金】：广东省医学科研基金资助项目(编号:B2012105)
【分类号】：R711.74

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