胎儿死亡的胎盘病理
发布时间：2018-12-27 11:21
【摘要】：人类胎盘是一个妊娠期的临时器官,对胎儿发育和正常妊娠的维持起重要作用。妊娠期间,胎盘在母体和胎儿间建立沟通的桥梁,为胎儿提供营养物质,进行气体交换和废物清除,并建立免疫耐受环境,保障半异体胎儿不被母体排斥;胎盘还可作为妊娠期重要的内分泌器官,协调胎儿发育及母体多器官的妊娠适应性应答。胎盘发育不良往往导致胎儿生长异常及多种妊娠并发症,严重情况下可导致胎儿死亡。文章阐述了生理状况下人类胎盘的结构和功能,描述了因胎儿生长受限(FGR)、子痫前期(PE)、妊娠期糖尿病(GDM)等造成胎儿死亡的胎盘病理特征,进而展望通过靶向胎盘干预妊娠期疾病的可能前景。
[Abstract]:Human placenta is a temporary organ of pregnancy, which plays an important role in fetal development and the maintenance of normal pregnancy. During pregnancy, the placenta establishes a bridge between mother and fetus to provide nutrition, gas exchange and waste removal for fetus, and establish immune tolerance environment to protect semi-allogenic fetus from maternal rejection. Placenta can also act as an important endocrine organ in pregnancy and coordinate fetal development and maternal multiple organ pregnancy adaptive response. Placental dysplasia often leads to abnormal fetal growth and multiple pregnancy complications, which can lead to fetal death in severe cases. This paper describes the structure and function of human placenta under physiological conditions and describes the placental pathological characteristics of fetal death caused by fetal growth restriction (FGR),) preeclampsia (PE), gestational diabetes mellitus (GDM) and so on. The possible prospect of intervention of gestational diseases by targeting placenta is also prospected.
【作者单位】： 中国科学院动物研究所干细胞与生殖生物学国家重点实验室;
【分类号】：R714.5
本文编号：2392985
[Abstract]:Human placenta is a temporary organ of pregnancy, which plays an important role in fetal development and the maintenance of normal pregnancy. During pregnancy, the placenta establishes a bridge between mother and fetus to provide nutrition, gas exchange and waste removal for fetus, and establish immune tolerance environment to protect semi-allogenic fetus from maternal rejection. Placenta can also act as an important endocrine organ in pregnancy and coordinate fetal development and maternal multiple organ pregnancy adaptive response. Placental dysplasia often leads to abnormal fetal growth and multiple pregnancy complications, which can lead to fetal death in severe cases. This paper describes the structure and function of human placenta under physiological conditions and describes the placental pathological characteristics of fetal death caused by fetal growth restriction (FGR),) preeclampsia (PE), gestational diabetes mellitus (GDM) and so on. The possible prospect of intervention of gestational diseases by targeting placenta is also prospected.
【作者单位】： 中国科学院动物研究所干细胞与生殖生物学国家重点实验室;
【分类号】：R714.5
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，本文编号：2392985
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