含铜宫内节育器中吲哚美辛体外释放规律的研究

发布时间：2018-12-28 07:11

【摘要】：目的:测定含铜宫内节育器(CuIUD)中吲哚美辛(IMC)在体外模拟宫腔液中的释放规律。方法:以体外模拟宫腔液作为提取介质,在37±0.5℃条件下静态释放IMC,然后通过高效液相色谱(HPLC)检测IMC的释放量。结果:IMC释放试验的前期释放量有较大(2.2~2.5 mg)的药物突释现象,释放率占载药量的10%,中期IMC的日均释放量逐渐变得缓慢,后期IMC的日均释放量趋于稳定。整个周期的释放量为7~12 mg,释放率占载药量的36%~49%。结论:建立了HPLC测定IMC在模拟宫腔液释放量的方法,且IMC体外累积释放率呈幂函数释放规律,每日释放量呈逐日下降趋势。
[Abstract]:Aim: to determine the release of indomethacin (IMC) from copper-containing intrauterine device (CuIUD) in simulated uterine fluid in vitro. Methods: in vitro simulated uterine fluid was used as the extraction medium. IMC, was released statically at 37 卤0.5 鈩，

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