宫颈癌组织中真核细胞翻译起始因子4E和血管内皮生长因子的表达及意义

发布时间：2018-12-28 12:21

【摘要】：目的探讨宫颈癌组织中真核细胞翻译起始因子4E(e IF4E)和血管内皮生长因子(VEGF)的表达及意义。方法随机选取50例宫颈癌患者作为研究对象(观察组),并随机采集20例患者的癌旁正常组织作为对照组。分别测定e IF4E和VEGF在50例宫颈癌和20例癌旁正常组织标本中的表达,分析其与有关参数的相关性。结果癌旁正常组织中e IF4E和VEGF阳性率均为15.00%,显著低于宫颈癌组织中e IF4E(50.00%)和VEGF(60.00%)的阳性率,e IF4E和VEGF的表达均与宫颈癌组织的分化程度、浸润程度、淋巴转移和静脉转移密切相关(P0.05),而与年龄、肿瘤大小关系不大(P0.05)。结论 e IF4E和VEGF参与宫颈癌组织细胞的分化、浸润和转移,促进肿瘤恶化和癌症发展。
[Abstract]:Objective to investigate the expression and significance of eukaryotic translation initiation factor 4e (e IF4E) and vascular endothelial growth factor (VEGF) in cervical carcinoma. Methods 50 patients with cervical cancer were randomly selected as the study group, and 20 normal tissues were randomly collected as the control group. The expression of e IF4E and VEGF in 50 cases of cervical carcinoma and 20 cases of adjacent normal tissues were detected, and the correlation between e IF4E and related parameters was analyzed. Results the positive rates of e IF4E and VEGF in adjacent normal tissues were 15.00, which were significantly lower than those in cervical cancer tissues (50.00%) and VEGF (60.00%). The expression of e IF4E and VEGF were both correlated with the differentiation of cervical carcinoma. Infiltration degree, lymphatic metastasis and venous metastasis were closely related (P0.05), but not related to age and tumor size (P0.05). Conclusion e IF4E and VEGF are involved in the differentiation, invasion and metastasis of cervical carcinoma, and promote the progression of cancer.
【作者单位】：西安交通大学医学院第一附属医院妇产科;
【基金】：陕西省科技攻关项目(编号:K13-01-13)
【分类号】：R737.33

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