外周血与肿瘤组织膜联蛋白A3表达对卵巢上皮癌铂类耐药的预测价值

发布时间：2019-01-11 20:36

【摘要】：目的比较外周血与肿瘤组织膜联蛋白A3(Annexin A3)表达对卵巢上皮癌铂类耐药的预测价值。方法选择2010年2月至2012年2月该院术后行以铂类为基础化疗,且完成随访的72例初治卵巢上皮癌患者,按照铂类耐药评价标准分为铂类化疗敏感组54例和铂类化疗耐药组18例,采用化学发光免疫分析法检测外周血Annexin A3水平;采用免疫组织化学染色检测肿瘤组织Annexin A3水平;通过绘制受试者工作特征(ROC)曲线分析外周血与肿瘤组织Annexin A3对铂类耐药的预测价值。结果铂类敏感组外周血Annexin A3水平显著低于铂类耐药组,差异有统计学意义(P0.05),铂类敏感组肿瘤组织Annexin A3表达阳性率显著低于铂类耐药组(P0.05)。外周血Annexin A3低浓度组中位生存期(31.2个月)显著高于高浓度组(23.1个月),差异有统计学意义(P0.05);组织Annexin A3低表达组中位生存期(35.2个月)显著高于高表达组(20.4个月),差异有统计学意义(P0.05)。多因素分析显示,血清与肿瘤组织Annexin A3表达水平是影响铂类耐药的独立危险因素(均P0.05)。外周血Annexin A3预测铂类耐药的ROC曲线下面积(AUC)为0.821;组织Annexin A3预测铂类耐药的AUC为0.763;外周血Annexin A3预测铂类耐药的AUC显著高于组织Annexin A3。结论铂类耐药的卵巢上皮癌患者外周血与肿瘤组织Annexin A3表达水平均显著升高,外周血Annexin A3对铂类耐药的预测价值优于组织Annexin A3。
[Abstract]:Objective to compare the predictive value of Annexin A 3 expression in peripheral blood and tumor tissues for platinum resistance in epithelial ovarian carcinoma. Methods from February 2010 to February 2012, 72 patients with newly diagnosed ovarian epithelial carcinoma were treated with platinum-based chemotherapy. According to the criteria of platinum resistance evaluation, the patients were divided into two groups: platinum chemosensitivity group (n = 54) and platinum-resistant group (n = 18). The level of Annexin A3 in peripheral blood was detected by chemiluminescence immunoassay. Immunohistochemical staining was used to detect the level of Annexin A 3 in tumor tissues, and the predictive value of Annexin A 3 to platinum resistance in peripheral blood and tumor tissues was analyzed by drawing the (ROC) curve. Results the level of Annexin A3 in peripheral blood of platinum sensitive group was significantly lower than that of platinum resistant group (P0.05), and the positive rate of Annexin A3 expression in platinum sensitive group was significantly lower than that in platinum resistant group (P0.05). The median survival time (31.2 months) in the low concentration group of peripheral blood Annexin A3 was significantly higher than that in the high concentration group (23.1 months), and the difference was statistically significant (P0.05). The median survival time of Annexin A3 low expression group (35.2 months) was significantly higher than that of high expression group (20.4 months), the difference was statistically significant (P0.05). Multivariate analysis showed that the expression of Annexin A3 in serum and tumor tissues was an independent risk factor for platinum resistance (P0.05). The area under the ROC curve of Annexin A3 was 0.821, the AUC of tissue Annexin A3 was 0.763.The AUC of peripheral blood Annexin A3 was significantly higher than that of tissue Annexin A3. Conclusion the expression of Annexin A 3 in peripheral blood and tumor tissues of patients with platinum resistant ovarian epithelial carcinoma was significantly increased, and the value of Annexin A 3 in predicting platinum resistance was superior to that in Annexin A 3.
【作者单位】：武警四川总队医院检验科;武警四川总队医院妇产科;
【分类号】：R737.31

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