卵巢储备功能下降相关因素的logistic回归分析

发布时间：2019-01-23 10:49

【摘要】：目的:探讨导致卵巢储备功能下降(DOR)的相关因素。方法:选取2012年5月~2014年5月在天津市中心妇产科医院生殖医学中心接受常规体外受精(IVF)或卵胞浆内单精子注射(ICSI)治疗的卵巢储备功能下降患者200例和非DOR患者200例(对照组)。采用logistic回归分析方法分析患者年龄、体重指数(BMI)、不孕年限、吸烟史、染色体、痛经史、初潮年龄、月经周期、经期、孕次、初次性生活、初次妊娠年龄、人流次数、药流次数、子宫内膜异位症、手术史、雄激素水平、血型、促排卵次数与DOR的关系。结果:最终进入logistic回归模型参数包括人流次数(OR=2.329)、促排卵次数(OR=9.578)、子宫内膜异位症史(OR=5.836)、初潮年龄(OR=0.318)、手术史(OR=3.409)。结论:人流次数、促排卵次数、子宫内膜异位症病史及手术史均为DOR危险因素,初潮年龄为DOR保护因素。
[Abstract]:Objective: to investigate the factors related to the decrease of ovarian reserve function (DOR). Methods: from May 2012 to May 2014, 200 patients with decreased ovarian reserve function who were treated with conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at the Center of Reproductive Medicine, Tianjin Center of Obstetrics and Gynecology, were selected. There were 200 cases of non DOR patients (control group). Age, body mass index (BMI),) infertility, smoking history, chromosome, dysmenorrhea, menarche age, menstrual cycle, pregnancy, first sexual life, age of first pregnancy, number of abortion were analyzed by logistic regression analysis. The relationship between drug flow, endometriosis, surgical history, androgen level, blood type, ovulation promoting frequency and DOR. Results: the parameters of logistic regression model included abortion times (OR=2.329), ovulation promotion (OR=9.578), history of endometriosis (OR=5.836), age of menarche (OR=0.318) and history of operation (OR=3.409). Conclusion: the frequency of abortion, the number of ovulation, the history of endometriosis and the history of operation are all risk factors of DOR, and the age of menarche is the protective factor of DOR.
【作者单位】：天津医科大学;天津市中心妇产科医院生殖医学中心;
【分类号】：R714.8

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