二甲双胍对多囊卵巢综合征胰岛素抵抗患者卵巢间质血流影响的三维超声表现

发布时间：2019-01-25 09:26

【摘要】：目的运用三维能量多普勒超声定量检测多囊卵巢综合征(PCOS)胰岛素抵抗(IR)患者卵巢间质血流指数及相关参数,探讨二甲双胍PCOS-IR患者卵巢间质微循环血流的影响。方法选取PCOS-IR患者40例为观察组,正常排卵的已婚女性20例为对照组,观察组服用二甲双胍共3个周期。比较观察组与对照组及观察组治疗前后卵巢间质血流参数(VI、FI、VFI)、卵巢容积、卵泡数目及生殖内分泌指标的差异。结果观察组较对照组卵巢间质血流参数升高,观察组治疗3个月后卵泡数目减少,卵巢间质血流参数VI、FI、VFI降低、生殖内分泌LH、LH/FSH、T较治疗前降低,差异均有统计学意义(P0.05);卵巢容积减小,差异无统计学意义(P0.05)。结论二甲双胍可以改善PCOS-IR患者卵巢间质血流微循环状况,三维能量多普勒超声能为PCOS的治疗效果的评判提供卵巢血流动力学量化方案,具有一定临床价值。
[Abstract]:Objective to investigate the effect of metformin PCOS-IR on interstitial blood flow in patients with polycystic ovary syndrome (PCOS) with insulin resistance (IR) by using three dimensional power Doppler ultrasound. Methods 40 patients with PCOS-IR and 20 married women with normal ovulation were selected as observation group and control group. The observation group took metformin for 3 cycles. The difference of ovarian interstitial blood flow parameters (VI,FI,VFI), ovarian volume, follicle number and reproductive endocrine index before and after treatment were compared between the observation group and the control group and the observation group. Results compared with the control group, the blood flow parameters of the ovarian stroma in the observation group increased, the number of follicles decreased, the VI,FI,VFI of the interstitial blood flow parameters of the ovary decreased, and the reproductive endocrine LH,LH/FSH,T decreased after 3 months of treatment in the observation group. The difference was statistically significant (P0.05). Ovarian volume decreased, the difference was not statistically significant (P0.05). Conclusion metformin can improve the microcirculation of ovarian stroma in patients with PCOS-IR. Three-dimensional power Doppler ultrasound can provide a quantitative scheme of ovarian hemodynamics for evaluating the therapeutic effect of PCOS, and it has certain clinical value.
【作者单位】：广州中医药大学研究生院;广州中医药大学第一附属医院超声科;
【分类号】：R711.75

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