女性年龄对胚胎植入前遗传学诊断及筛查结局的影响

发布时间：2019-02-11 10:46

【摘要】：目的探讨女性年龄对胚胎植入前遗传学诊断及筛查(PGD/PGS)结局的影响。方法回顾性分析2015年1月1日至12月31日开展PGD/PGS治疗周期的149例患者,按女性年龄将患者分为3组:Ⅰ组10例(25岁)共36枚囊胚;Ⅱ组94例(25~34岁)共329枚囊胚;Ⅲ组45例(≥35岁)共89枚囊胚。比较各组之间的胚胎正常率和临床妊娠率。结果Ⅰ组、Ⅱ组、Ⅲ组的胚胎正常率分别为50.00%、50.15%、29.21%。Ⅰ组与Ⅲ组的胚胎正常率比较差异有统计学意义(χ~2=4.855,P0.05),Ⅱ组与Ⅲ组的胚胎正常率比较差异有统计学意义(χ~2=12.376,P0.05)。Ⅰ组、Ⅱ组、Ⅲ组的临床妊娠率分别为83.33%、82.50%、40.00%。Ⅰ组与Ⅲ组的临床妊娠率比较差异有统计学意义(χ~2=3.893,P0.05),Ⅱ组与Ⅲ组的临床妊娠率比较差异有统计学意义(χ~2=7.510,P0.05)。结论女性年龄对PGD/PGS结局有影响,当女性年龄≥35岁时会明显降低胚胎的正常率和临床妊娠率。
[Abstract]:Objective to investigate the effect of female age on the outcome of preimplantation genetic diagnosis and screening (PGD/PGS). Methods A retrospective analysis was made on 149 patients with PGD/PGS treatment cycle from January 1 to December 31, 2015. The patients were divided into 3 groups according to female age: group 鈪，

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