上皮性卵巢癌组织中FOXC1的表达变化及意义

发布时间：2019-02-12 17:54

【摘要】：目的探讨上皮性卵巢癌组织中叉头框蛋白C1(FOXC1)的表达变化及意义。方法选取良性上皮性卵巢瘤30例份、交界性上皮性卵巢瘤30例份、上皮性卵巢癌70例份,应用免疫组化SP法检测组织FOXC1、上皮性黏钙蛋白(E-cadherin)、波形蛋白(Vimentin)表达水平,比较其三者与临床病理参数的关系;随访患者3年,比较组织中FOXC1、E-cadherin和Vimentin表达阳性与阴性患者的3年累积生存率。结果 (1)与良性上皮性卵巢瘤组织比较,上皮性卵巢癌组织中FOXC1、E-cadherin表达阳性率降低,Vimentin表达阳性率升高(P均0.05)。(2)FOXC1阳性表达的卵巢癌组织中E-cadherin表达阳性率为28.6%(20/70)、Vimentin表达阳性率为15.7%(11/70),FOXC1表达与Ecadherin表达呈正相关(r=0.446,P=0.000),与Vimentin表达呈负相关(r=-0.295,P=0.014)。(3)上皮性卵巢癌组织中FOXC1蛋白表达与淋巴结转移、二元论分型、两组分级有关,E-cadherin、Vimentin蛋白表达与淋巴结转移、临床分期、二元论分型、两级分级有关(P均0.05)。(4)上皮性卵巢癌组织中FOXC1、E-cadherin阳性患者3年累积生存率分别为82.1%、80.6%,高于FOXC1、E-cadherin阴性患者69.0%、69.2%,Vimemtin阳性患者3年累积生存率为70%,低于Vimemtin阴性患者80%(P均0.05)。结论上皮性卵巢癌组织中FOXC1的表达降低,其表达缺失介导了卵巢的上皮间质转化,可能参与了卵巢癌的发生发展,并可评估其预后。
[Abstract]:Objective to investigate the expression and significance of fork box protein C1 (FOXC1) in epithelial ovarian carcinoma. Methods 30 cases of benign epithelial ovarian tumor, 30 cases of borderline epithelial ovarian tumor and 70 cases of epithelial ovarian carcinoma were selected. FOXC1, epithelial mucocalcin (E-cadherin) was detected by immunohistochemical SP method. The expression level of vimentin (Vimentin) was compared and its relationship with clinicopathological parameters was compared. The 3-year cumulative survival rates of FOXC1,E-cadherin and Vimentin positive and negative patients were compared. Results (1) the positive rate of FOXC1,E-cadherin expression in epithelial ovarian carcinoma was lower than that in benign ovarian carcinoma. The positive rate of Vimentin expression was 28.6% (20 / 70), Vimentin) in ovarian cancer tissues with increased FOXC1 expression (all P 0.05). (2), and the positive rate of E-cadherin expression was 15.7% (11 / 70) in 20% (70 / 70) ovarian cancer tissues. The expression of FOXC1 was positively correlated with the expression of Ecadherin (r = 0.446), and negatively correlated with the expression of Vimentin (r ~ (-0.295) P ~ (0.014). (_ 3). The expression of FOXC1 protein was correlated with lymph node metastasis and dualistic classification in epithelial ovarian carcinoma. The expression of Vimentin protein was related to lymph node metastasis, clinical stage, dualistic classification, and FOXC1, in epithelial ovarian carcinoma (all P 0. 05). (4). The 3-year cumulative survival rate of E-cadherin positive patients was 82.1 and 80.6, which was higher than that of 69.0 FOXC1,E-cadherin negative patients. The 3-year cumulative survival rate of Vimemtin positive patients was 70. It was lower than 80% of Vimemtin negative patients (all P 0. 05). Conclusion the expression of FOXC1 in epithelial ovarian carcinoma is decreased, and the loss of expression may mediate the epithelial interstitial transformation, which may be involved in the occurrence and development of ovarian cancer, and can be used to evaluate the prognosis of ovarian cancer.
【作者单位】：郑州大学第三附属医院;
【基金】：河南省科技厅科技攻关项目(162102310131);河南省科技厅科技攻关项目(142300410205)
【分类号】：R737.31

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