子宫内膜癌组织中RECK与MMP-9的表达及其临床意义
发布时间：2019-02-19 14:18
【摘要】：目的研究子宫内膜癌组织中RECK与MMP-9表达及其临床意义。方法选取于2012年4月至2015年1月期间在漯河医学高等专科学校第一、二附属医院住院手术切除并经病理确诊的内膜癌标本运用免疫组化S-P法进行检测,分析RECK和MMP-9的表达情况及其相关性。结果 RECK基因在内膜癌阳性表达率明显高于对照组,分别为35.0%和84.4%;内膜癌I期组阳性表达率明显高于Ⅱ-Ⅳ期组,分别为51.4%和12.0%,两两比较差异显著(P0.05)。MMP-9在正常内膜阳性率明显低于内膜癌组,分别为17.8%和76.7%;内膜癌I期组阳性率明显低于Ⅱ-Ⅳ期组,分别为65.7%和92.0%,二者比较差异显著(P0.05)。MMP-9的表达与RECK呈负相关(r=-0.390,P0.05)。结论 RECK及MMP-9的表达在子宫内膜癌发生发展中发挥一定作用并对预后的判断具有重要的意义。
[Abstract]:Objective to study the expression of RECK and MMP-9 in endometrial carcinoma and its clinical significance. Methods from April 2012 to January 2015, samples of endometrial carcinoma, which were surgically resected and confirmed by pathology in the first and second affiliated Hospital of Luohe Medical College, were detected by immunohistochemical S-P method. The expression of RECK and MMP-9 and their correlation were analyzed. Results the positive expression rate of RECK gene in endometrial carcinoma was 35.0% and 84.4%, respectively. The positive expression rate of MMP-9 in stage I group was significantly higher than that in stage 鈪，
本文编号：2426582
[Abstract]:Objective to study the expression of RECK and MMP-9 in endometrial carcinoma and its clinical significance. Methods from April 2012 to January 2015, samples of endometrial carcinoma, which were surgically resected and confirmed by pathology in the first and second affiliated Hospital of Luohe Medical College, were detected by immunohistochemical S-P method. The expression of RECK and MMP-9 and their correlation were analyzed. Results the positive expression rate of RECK gene in endometrial carcinoma was 35.0% and 84.4%, respectively. The positive expression rate of MMP-9 in stage I group was significantly higher than that in stage 鈪，
本文编号：2426582
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