不同孕期尿双酚A与孕妇甲状腺功能指标关联的初步研究

发布时间：2019-02-21 17:22

【摘要】：[目的]探讨上海市不同孕期孕妇的双酚A(BPA)暴露现状及其与甲状腺功能指标的关联。[方法]收集上海市7个区共210名孕妇(孕早、中、晚期各三分之一)的尿样,采用固相萃取-高效液相色谱串联质谱法(HPLC-MS/MS)测定尿液总BPA质量浓度,并检测血清中5个甲状腺功能指标的水平:游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)。了解不同孕期孕妇的BPA暴露水平,采用Pearson相关及多元线性回归分析尿BPA与血清甲状腺功能指标的关联。[结果]被检孕妇的尿液BPA检出率为95.7%,质量浓度范围为未检出~11.99μg/L,整体水平呈偏态分布,经尿比重校正后BPA质量浓度M(P_(25),P_(75))为0.53(0.36,0.83)μg/L,孕早、中、晚期BPA质量浓度差异无统计学意义。通过Pearson相关分析发现,孕早、晚期经尿比重校正的尿BPA质量浓度与血清TGAb水平呈正相关(r=0.396,P=0.002;r=0.440,P=0.000)。调整年龄、孕中BMI、孕周这些协变量后,两者仍呈正相关(b=0.369,95%CI:0.206~0.532,P=0.000)。尿BPA与其他甲状腺功能指标无相关性。[结论]上海市孕妇普遍存在BPA暴露,孕期BPA暴露可能影响血清TGAb水平。
[Abstract]:[objective] to investigate the present status of bisphenol A (BPA) exposure and its association with thyroid function in pregnant women with different pregnancies in Shanghai. [methods] urine samples of 210 pregnant women (1/3 in the first trimester, 1/3 in the second trimester and 1/3 in the late trimester) were collected from 7 districts of Shanghai. The total BPA concentration in urine was determined by solid phase extraction (SPE) and high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH), thyroglobulin (TGAb),) in serum were determined. Thyroid peroxidase antibody (TPOAb). To investigate the level of BPA exposure in pregnant women during different pregnancy, the correlation between urinary BPA and serum thyroid function index was analyzed by Pearson correlation and multivariate linear regression analysis. [results] the detection rate of urine BPA in pregnant women was 95.70.The range of mass concentration was from 11.99 渭 g / L to 11.99 渭 g / L, and the whole level was skewed. The BPA concentration M (P25) was corrected by urine specific gravity. P _ (75) was 0.53 (0.36 卤0.83) 渭 g / L, and there was no significant difference in BPA concentration in early, middle and late pregnancy. By Pearson correlation analysis, it was found that there was a positive correlation between urinary BPA concentration corrected by specific gravity in early and late pregnancy and serum TGAb level (r = 0.396p ~ (0.002) P ~ (0.002) P ~ (0.440) P ~ (0.000). After adjusting the age, the covariables of BMI, in pregnancy were positively correlated with each other (CI: 0.206 ~ 0.532). There was no correlation between urinary BPA and other thyroid function indexes. [conclusion] BPA exposure is common in pregnant women in Shanghai, and BPA exposure during pregnancy may affect serum TGAb level.
【作者单位】：上海市疾病预防控制中心慢性非传染病与伤害防治所;
【基金】：上海市卫生计生委面上项目(编号:201440617) 第四轮公共卫生三年行动计划重点学科(编号:15GWZK0801)
【分类号】：R715.3

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