辅助生殖技术中影响出生婴儿性别比的相关因素分析

发布时间：2019-02-25 15:23

【摘要】：目的探讨辅助生殖技术(ART)中影响出生婴儿性别比的相关因素。方法收集2008年1月~2014年3月于我院接受ART治疗并成功分娩的4348个周期的患者的临床资料,包括男女双方年龄、不孕原因、授精方式、移植胚胎期别、移植胚胎类型、分娩类型(单胎、双胎分娩)、既往ART流产次数、ART分娩次数和分娩的5607名新生儿的性别,分析不同因素对于分娩新生儿性别的影响。结果共有3019名男婴和2588名女婴出生,性别比为116∶100;单胎分娩的3087名新生儿出生性别比为117∶100;双胎分娩的2520名新生儿性别比为116:100;经ART治疗一胎分娩5542名新生儿出生性别比为117∶100;二胎分娩新生儿65名,出生性别比为117∶100。在单胎妊娠活产婴儿中,若女方或男方高龄,出生男婴比例较对照组(年龄35岁)显著增高(分别为58.4%vs 52.8%,P=0.012;56.4%vs 52.3%;P=0.026),同时观察到ICSI组出生男婴比例较IVF组明显较低(45.7%vs 55.6%,P0.001),其它因素则对出生婴儿性别比无显著影响;在双胎妊娠活产新生儿组中,上述不同因素对出生新生儿性别比均无显著性差异。ART治疗后生育一胎新生儿中,女方高龄组出生男婴比例显著高于对照组(57.4%vs 53.0%,P=0.009),并可知ICSI组中出生男婴比例显著低于IVF组(48.6%vs 55.4%,P=0.001);而ART治疗后生育二胎新生儿中,不同因素各组间出生婴儿性别比均无显著性差异。单因素Logistic回归分析提示,女方年龄(OR:0.836,95%CI 0.731~0.955,P0.05)、授精方式(OR∶1.151,95%CI 1.027~1.289,P0.05)对出生婴儿性别比产生的影响有统计学意义,其它因素对出生婴儿性别比则无显著影响。进一步行多因素Logistic回归分析提示,无独立的预测因素。结论经ART治疗后高龄女性生育男性婴儿比例更高,在单胎活产婴儿中男方高龄与出生男婴比例增加相关,而ICSI授精方式较IVF女性婴儿比例更高。
[Abstract]:Objective to explore the related factors of sex ratio in assisted reproductive technology (ART). Methods from January 2008 to March 2014, the clinical data of 4348 patients who received ART treatment and successfully delivered in our hospital were collected, including the age of both sexes, the cause of infertility, the way of insemination, the stage of embryo transfer, and the type of embryo transfer. The types of delivery (single and twin births), the number of previous ART miscarriages, the times of ART deliveries and the sex of 5607 newborns delivered were analyzed. The effects of different factors on the sex of the newborns were analyzed. Results A total of 3019 male and 2588 female infants were born with a sex ratio of 116 to 100, a sex ratio of 117 to 100 for 3087 newborns in a single birth, and a sex ratio of 116 to 100 to 2520 for twin births. After ART treatment, the birth sex ratio of 5542 newborns in one birth was 117 脳 100, and the sex ratio of birth to birth was 117 / 100 in the second and 65 newborns in the second birth. In single pregnancy, the proportion of male births was significantly higher than that of the control group (58.4%vs 52.8%, P0.01256.4% vs 52.3%) if the female or male was older than the control group (35 years old). At the same time, the ratio of boys born in ICSI group was significantly lower than that in IVF group (45.7%vs 55.6%, P0.001), while other factors had no significant effect on the sex ratio of newborn infants. There was no significant difference between the above factors and the sex ratio of the newborn in the twin pregnancy live birth group. After ART treatment, there was no significant difference in the sex ratio of the single born newborn. The percentage of boys born in the elderly group was significantly higher than that in the control group (57.4%vs 53.0%, P < 0.009), and the percentage of boys born in the ICSI group was significantly lower than that in the IVF group (48.6%vs 55.4%, P < 0.001). There was no significant difference in the sex ratio between the groups with different factors in the second birth after ART treatment. Univariate Logistic regression analysis showed that female age (OR:0.836,95%CI 0.731 脳 0.955, P0.05) and insemination style (OR:1.151,95%CI 1.027 / 1.289, P0.05) had a statistically significant impact on the sex ratio of babies at birth. Other factors had no significant effect on the sex ratio of infants. Further multivariate Logistic regression analysis showed that there were no independent predictors. Conclusion after treatment with ART, the proportion of male infants born to older women is higher, and the proportion of boys born in single live births is related to the age of males, while the proportion of insemination mode of ICSI is higher than that of female infants of IVF. [WT5 "HZ] conclusion [WT5" BZ]
【作者单位】：南方医科大学南方医院妇产科生殖医学中心;广东省妇幼保健院生殖医学中心;
【基金】：广东省科技计划项目(2013B0022000017)
【分类号】：R714.8

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