南京地区年轻女性HPV感染及宫颈病变情况分析

发布时间：2019-03-22 20:32

【摘要】：目的:探讨南京地区年轻女性人乳头瘤病毒(HPV)流行病学现状,旨在为HPV感染的防治提供科学依据。方法:回顾2014年1月至2015年12月在中大医院妇产科门诊及相关科室就诊并行HPV检测的896例年轻女性(18~30岁)的临床及病理资料,并初步探讨年轻人群中HPV感染与宫颈病变的相关性。结果:在纳入的896例年轻女性中,HPV阳性者共281例,占31.36%。高危型人乳头瘤病毒(hrHPV)检出率最高的前5种型别分别为HPV52、HPV16、HPV53、HPV39及HPV58;低危型人乳头瘤病毒(lr HPV)检出率最高的前3种型别分别为HPV81、HPV6及HPV11。132例年轻患者行阴道镜下活检,根据组织病理74例纳入宫颈良性病变组,平均年龄为26岁;19例纳入低级别宫颈鳞状上皮内病变(LSIL)组,平均年龄为27.3岁;34例纳入高级别宫颈鳞状上皮内病变(HSIL)组,平均年龄28.2岁;5例确诊为宫颈癌,实足年龄均为30岁。不同级别的宫颈病变组间存在年龄差异,且有统计学意义(P0.05)。在伴有HPV感染的年轻女性中,HSIL的发生率为45.68%,显著高于不伴HPV感染的年轻女性(3.92%),差异有统计学意义(P0.05)。结论:南京地区年轻女性最常见的hrHPV分别为HPV52、HPV16、HPV53、HPV39及HPV58。伴有hrHPV感染的年轻女性,随着年龄增长,更易出现HSIL。
[Abstract]:Objective: to investigate the epidemiological status of human papillomavirus (HPV) in young women in Nanjing, in order to provide scientific basis for the prevention and treatment of HPV infection. Methods: the clinical and pathological data of 896 young women (18 years old) who were examined by HPV from January 2014 to December 2015 in gynaecology and obstetrics department and related departments of CUHK Hospital were retrospectively reviewed. And to explore the correlation between HPV infection and cervical lesions in young population. Results: of the 896 young women included, 281 (31.36%) were HPV positive. The first five types of high risk human papillomavirus (hrHPV) were HPV52,HPV16,HPV53,HPV39 and HPV58;, respectively. The first three types with the highest detection rate of low-risk human papillomavirus (lr HPV) were HPV81,HPV6 and HPV11.132, respectively, who underwent colposcopy biopsy. According to histopathology, 74 cases were included in the benign cervical lesions group, the average age was 26 years. 19 cases were enrolled in low-grade cervical squamous intraepithelial lesion (LSIL) group, the average age was 27.3 years, 34 cases were enrolled in high-grade cervical squamous intraepithelial lesion (HSIL) group, the average age was 28.2 years. Five cases were diagnosed as cervical cancer with full age of 30 years old. There was age difference between different grades of cervical lesions, and there was statistical significance (P0.05). Among the young women with HPV infection, the incidence of HSIL was 45.68%, which was significantly higher than that of young women without HPV infection (3.92%), the difference was statistically significant (P0.05). Conclusion: the most common hrHPV of young women in Nanjing is HPV52,HPV16,HPV53,HPV39 and HPV58., respectively. Young women with hrHPV infection are more likely to develop HSIL. as they age
【作者单位】：无锡市第四人民医院妇产科;东南大学附属中大医院妇产科;
【基金】：中央高校基本科研业务费专项资金项目(JSZZ15-0030) 江苏省普通高校研究生科研创新计划资助项目(JSZZ15-0030)
【分类号】：R737.33

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