低分子肝素联合硫酸镁治疗妊娠期高血压的临床效果

发布时间：2019-03-23 16:02

【摘要】：目的:探讨低分子肝素联合硫酸镁治疗妊娠期高血压的临床效果。方法:选取中山市博爱医院2014年5月至2016年6月收治的88例妊娠期高血压患者,随机分为治疗组与对照组。对照组采取单一硫酸镁治疗,治疗组则采取低分子肝素联合硫酸镁治疗。观察并对比两组患者的疗效情况、记录两组患者治疗前后的血小板计数以及凝血酶原时间、测定红细胞压积与D-二聚体的结果、统计产后2 h内出血量情况。结果:治疗后,两组患者的红细胞压积与D-二聚体水平均较治疗前有明显改善,治疗组患者的红细胞压积与D-二聚体水平明显低于对照组患者,差异具有统计学意义(P0.05);两组患者治疗前与治疗后的血小板计数以及凝血酶原时间比较,差异均无统计学意义(P0.05);治疗组患者产后2 h内的出血量与对照组比较,差异无统计学意义(P0.05)。结论:针对妊娠期高血压患者,对其采取低分子肝素联合硫酸镁治疗的效果明显优于单一实施硫酸镁治疗,能够显著缓解患者体内的高度血凝状态的同时不增加患者的凝血障碍与产后出血量。
[Abstract]:Objective: to investigate the clinical effect of low molecular weight heparin (LMWH) combined with magnesium sulfate on hypertensive complicating pregnancy. Methods: from May 2014 to June 2016 in Boai Hospital of Zhongshan City, 88 patients with hypertensive complicating pregnancy were randomly divided into two groups: treatment group and control group. The control group was treated with single magnesium sulfate, while the treatment group was treated with low molecular weight heparin combined with magnesium sulfate. The curative effects of the two groups were observed and compared. The platelet count and prothrombin time were recorded before and after treatment. The hematocrit and D-dimer were measured. The bleeding volume within 2 hours after delivery was counted. Results: after treatment, the levels of hematocrit and D-dimer in the two groups were obviously improved, and the levels of hematocrit and D-dimer in the treatment group were significantly lower than those in the control group. The difference was statistically significant (P0.05); There was no significant difference in platelet count and prothrombin time between the two groups before and after treatment (P0.05). There was no significant difference in the bleeding volume between the treatment group and the control group within 2 hours after delivery (P0.05). Conclusion: low molecular weight heparin (LMWH) combined with magnesium sulfate is superior to magnesium sulfate alone in the treatment of hypertensive complicating pregnancy. It can significantly relieve the high hemagglutination state of the patient without increasing the coagulation disorder and postpartum hemorrhage.
【作者单位】： 中山市博爱医院;
【分类号】：R714.246

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