孕激素抑制LH峰在控制性卵巢刺激过程中的疗效观察

发布时间：2019-04-11 17:28

【摘要】：目的:探讨在控制性卵巢刺激(COS)过程中应用孕激素抑制黄体生成素(LH)峰的临床效果。方法:回顾性分析83例行体外受精/卵胞质内单精子注射-冻融胚胎移植(IVF/ICSI-FET)患者的资料,所有患者均采用孕激素联合促性腺激素方案,83个取卵周期共完成了92个FET周期,统计分析促排卵过程中的激素变化、胚胎实验室情况及妊娠结局。结果:在促排卵过程中,LH持续低水平,基础、中期(月经第9~11日)、诱发排卵当日LH水平分别为3.85±2.03 IU/L、3.64±2.01 IU/L、2.62±1.77 IU/L,未监测到LH峰。h MG的用药剂量为1 964.76±468.73 IU,孕激素(商品名:安琪坦)的用药剂量为2.05±0.34 g。平均获卵数为10.9±6.1,每个取卵周期平均冷冻5.0±2.5个胚胎。FET后临床妊娠率为52.17%(48/92),胚胎种植率为39.34%(72/183),流产率为10.42%(5/48)。结论:孕激素能够有效抑制LH峰,孕激素联合Gn促排卵方案为基于FET的促排卵技术提供了新的备选方案。
[Abstract]:Objective: to investigate the clinical effect of progesterone on inhibiting luteinizing hormone (LH) peak during controlled ovarian stimulation of (COS). Methods: the data of 83 patients with in vitro fertilization / intracytoplasmic sperm injection-frozen-thawed embryo transfer (IVF/ICSI-FET) were retrospectively analyzed. All patients were treated with progesterone combined with gonadotropin. A total of 92 FET cycles were completed in 83 ovulatory cycles. Hormone changes, embryo laboratory conditions and pregnancy outcomes during ovulation induction were statistically analyzed. Results: during the course of ovulation induction, the level of LH remained low, basal, and the level of LH on the day of ovulation induction was 3.85 卤2.03 IU/L,3.64 卤2.01 IU/L,2.62 卤1.77 IU/L, at the middle stage (from 9 to 11 days of menstruation). The dose of. H MG not detected in LH peak was 1 964.76 卤468.73 IU, (trade name: Angel), which was 2.05 卤0.34 g 路mol ~ (- 1). The average number of fetched eggs was 10.9 卤6.1, and the average cryopreservation was 5.0 卤2.5 embryos per cycle. The clinical pregnancy rate and implantation rate were 52.17% (48 / 92) and 39.34% (72 / 183), respectively. The abortion rate was 10.42% (5 / 48). Conclusion: progesterone can effectively inhibit LH peak. Progesterone combined with Gn provides a new alternative for FET-based ovulation induction technology.
【作者单位】：上海交通大学医学院附属第九人民医院辅助生殖科;上海交通大学医学院九院临床医学院;上海中医药大学附属曙光医院妇产科;
【分类号】：R714.8

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