孕期抗菌药物对孕妇妊娠结局影响分析

发布时间：2019-04-17 17:55

【摘要】：目的研究孕期抗菌药物使用对妊娠期感染性疾病患者的分娩结局影响,为临床孕期抗菌药物治疗提供指导。方法回顾性分析医院2013年1月-2015年4月收治的妊娠期合并感染性疾病患者161例,根据患者孕中是否使用抗菌药物分为使用组(72例)和未使用组(89例),另选门诊接受健康体检的正常孕妇80例为对照组,统计所有患者感染类型和使用组抗菌药物种类,采用SPSS19.0软件对3组孕妇妊娠结局、不良妊娠种类及新生儿发育指标进行统计分析,采用多因素logistic回归分析不良妊娠因素。结果使用组患者第三代头孢菌素类抗菌药物使用率明显高于其他种类抗菌药物(P0.05),未使用组的不良妊娠发生率(53.93%)明显高于使用组(26.39%)(P0.05),使用组和对照组胎儿在双顶径、股骨长度、出生胎龄及出生体质量均明显优于未使用组(P0.01);多因素logistic分析结果显示,感染与不良妊娠发生存在明显相关性(P=0.003,95%CI:0.035~0.631)。结论妊娠期合并感染性疾病可明显增加孕妇不良妊娠发生率,严重危害母婴健康,同时合理使用抗菌药物治疗可有效预防不良妊娠的发生,改善新生儿生长发育。
[Abstract]:Objective to study the effect of antibacterials during pregnancy on delivery outcome of patients with infectious diseases of pregnancy, and to provide guidance for clinical treatment of antibiotics during pregnancy. Methods 161 pregnant patients with infectious diseases during pregnancy from January 2013 to April 2015 were analyzed retrospectively. According to whether they used antibiotics during pregnancy, they were divided into two groups: use group (72 cases) and untreated group (89 cases). Another 80 normal pregnant women who received health examination were selected as the control group. The infection types of all the patients and the types of antibacterial drugs used in the group were counted, and the pregnancy outcomes of the three groups of pregnant women were analyzed by SPSS19.0 software. The types of bad pregnancy and the indexes of neonatal development were analyzed statistically, and the factors of bad pregnancy were analyzed by multi-factor logistic regression. Results the use rate of the third generation cephalosporins in the use group was significantly higher than that in the other antibiotics (P0.05). The incidence of bad pregnancy in the non-use group (53.93%) was significantly higher than that in the use group (26.39%) (P0.05). The fetal biparietal diameter, femur length, fetal age and birth weight in the two groups were significantly better than those in the control group (P0.01). Multivariate logistic analysis showed that there was a significant correlation between infection and adverse pregnancy (P < 0. 003,95% CI 0. 035, 0. 631). Conclusion pregnancy complicated with infectious diseases can significantly increase the incidence of bad pregnancy in pregnant women and seriously endanger the health of mothers and infants. At the same time, rational use of antibiotics can effectively prevent the occurrence of bad pregnancy and improve the growth and development of newborns.
【作者单位】：浙江舟山群岛新区旅游与健康职业学院健康分院;舟山市人民医院妇产科;
【分类号】：R714.251

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