生长激素、山莨菪碱预防宫腔粘连分离术后再粘连的临床研究

发布时间：2019-04-23 20:16

【摘要】：目的:探讨生长激素、山莨菪碱预防宫腔粘连分离术后再粘连的临床价值。方法:选取成功行宫腔镜下宫腔粘连分离术的中重度宫腔粘连患者65例,根据术后是否联合应用生长激素、山莨菪碱,将研究对象分成对照组(n=22)、生长激素(growth hormone,GH)组(n=18)、GH+654-2组(n=25),对照组术后采取常规的综合治疗方法;GH组在对照组的基础上,联合皮下注射生长激素;GH+654-2组在GH组的基础上,术后口服山莨菪碱。术后3个月,比较3组患者的宫腔再粘连率、月经改善情况及月经周期同一时间的子宫内膜厚度。结果:比较3组患者的术前宫腔粘连程度、月经情况及子宫内膜厚度,差异均无统计学意义(均P0.05);术后对照组、GH组、GH+654-2组的子宫内膜厚度分别为:(5.18±0.21)、(5.94±0.27)、(5.72±0.26)mm;月经改善率分别为:68.2%、88.9%、96.0%;GH组、GH+654-2组的子宫内膜厚度及月经改善率均优于对照组,差异有统计学意义(P0.05),但GH组与GH+654-2组比较,差异无统计学意义(P0.05);对照组的宫腔再粘连率(31.8%)高于GH组(27.8%)与GH+654-2组(24.0%),但3组间差异无统计学意义(P0.05)。结论:生长激素、山莨菪碱联合以往的综合辅助治疗方法,能够增加宫腔粘连分离术后的子宫内膜厚度,有利于月经的恢复,对临床疗效的提高具有积极意义。
[Abstract]:Objective: to investigate the clinical value of growth hormone and anisodamine in preventing readhesion after uterine cavity adhesion separation. Methods: 65 cases of moderate and severe conglutination of uterine cavity were selected and divided into control group (n = 22), growth hormone (growth hormone, (GH) according to the combination of growth hormone (GH) and anisodamine (Anisodamine) after operation. The patients were divided into two groups: control group (n = 22), growth hormone group (GH). The patients in GH group (n = 18), GH 654, n = 25) were treated with conventional comprehensive therapy after operation. On the basis of control group, GH group combined with subcutaneous injection of growth hormone, and GH 654 / 2 group took anisodamine orally after operation on the basis of GH group. Three months after operation, the rate of uterine cavity readhesion, the improvement of menstruation and the thickness of endometrium at the same time in menstrual cycle were compared among the three groups. Results: there was no significant difference in the degree of uterine cavity adhesion, menstruation and endometrial thickness among the three groups before operation (all P0.05). The endometrial thickness of control group, GH group and GH 654 group were (5.18 卤0.21), (5.94 卤0.27), (5.72 卤0.26) mm;, respectively: 68.2%, 88.9%, 96.0%, respectively. The endometrial thickness and menstrual improvement rate of GH group and GH 654 / 2 group were better than those of control group (P0.05), but there was no significant difference between GH group and GH 654 group (P0.05). The readhesion rate of uterine cavity in control group (31.8%) was higher than that in GH group (27.8%) and GH 654 / 2 group (24.0%), but there was no significant difference among the three groups (P0.05). Conclusion: growth hormone, anisodamine combined with the previous comprehensive adjuvant therapy can increase the endometrial thickness after separation of uterine adhesions, which is beneficial to the recovery of menstruation, and has positive significance for the improvement of clinical curative effect.
【作者单位】：河南科技大学第一附属医院妇产科;
【分类号】：R713.4

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