核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级正相关

发布时间：2019-04-24 01:30

【摘要】：目的比较核仁素在宫颈鳞癌、宫颈上皮内瘤变和正常宫颈组织表达的差异,探讨核仁素表达增高在宫颈鳞癌发生发展中的作用。方法用免疫组化检测50例宫颈鳞癌、65例宫颈上皮内瘤变和正常宫颈组织中核仁素的表达,比较核仁素在3种组织中表达的差异,并分析核仁素表达水平与宫颈鳞癌和宫颈上皮内瘤变病理分级的关系。结果宫颈鳞癌核仁素阳性表达率显著高于宫颈上皮内瘤变和正常宫颈组织,宫颈上皮内瘤变核仁素阳性表达率显著高于正常宫颈组织,P0.01。Allred免疫组化半定量评分显示,核仁素表达量在宫颈鳞癌组织(7.6±0.3)显著高于宫颈上皮内瘤变(6.1±0.2)和正常宫颈组织(3.0±0.2),P0.01。在宫颈上皮内瘤变显著高于正常宫颈组织,P0.01。核仁素表达量在中-低分化宫颈鳞癌(7.9±0.1)显著高于高分化鳞癌(7.0±0.2),在高级别上皮内瘤变(6.0±0.1)显著高于低级别上皮内瘤变组织(4.0±0.2),P0.01。结论宫颈鳞状上皮在癌变过程中核仁素表达量增高,核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级呈正相关。
[Abstract]:Aim to compare the expression of nuclein in cervical squamous cell carcinoma, cervical intraepithelial neoplasia and normal cervical tissue, and to explore the role of nuclein expression in the carcinogenesis and development of cervical squamous cell carcinoma. Methods the expression of nuclein was detected by immunohistochemistry in 50 cases of cervical squamous cell carcinoma, 65 cases of cervical intraepithelial neoplasia and normal cervical tissues. The relationship between the expression of nuclein and the pathological grade of cervical squamous cell carcinoma and cervical intraepithelial neoplasia was analyzed. Results the positive expression rate of nuclein in cervical squamous cell carcinoma was significantly higher than that in cervical intraepithelial neoplasia and normal cervical tissue. The positive expression rate of nuclein in cervical intraepithelial neoplasia was significantly higher than that in normal cervical tissue. The expression of nuclein in cervical squamous cell carcinoma (7.6 卤0.3) was significantly higher than that in cervical intraepithelial neoplasia (6.1 卤0.2) and normal cervical tissue (3.0 卤0.2), P 0.01. The change of cervical intraepithelial neoplasia was significantly higher than that of normal cervical tissue, P0.01. The expression of nuclein in moderately-poorly differentiated cervical squamous cell carcinoma (7.9 卤0.1) was significantly higher than that in well-differentiated cervical squamous cell carcinoma (7.0 卤0.2). High grade intraepithelial neoplasia (6.0 卤0.1) was significantly higher than that of low grade intraepithelial neoplasia (4.0 卤0.2), P 0.01. Conclusion the expression of nuclein is increased in cervical squamous cell carcinoma and cervical intraepithelial neoplasia, and the expression of nuclein is positively correlated with the pathological grade of cervical squamous cell carcinoma and cervical intraepithelial neoplasia.
【作者单位】： 湘南学院病理学教研室//附属医院病理科;
【分类号】：R737.33

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