中国人群HLA-DRB1基因多态性与宫颈癌易感性的Meta分析

发布时间：2019-04-24 20:06

【摘要】：目的应用Meta分析探讨宫颈癌的相关易感基因人白细胞抗原-DRB1基因的不同位点多态性与宫颈癌发病风险的关系。方法通过检索中国学术期刊全文数据库(CNKI)、维普科技期刊数据库(VIP)、万方数据、PubMed.Elsevier.Springer Link和口Cochrane Library database数据库,应用关键词或主题词“宫颈癌”、“等位基因”、“基因多态性”、“人类白细胞抗原”、‘'HLA-DRB"搜索从各数据库建库起到2013年5月份发表的有关人类白细胞抗原基因(HLA-DRB1)基因多态性与宫颈癌易感性关系的病例对照研究的中英文文献,全面检索相关文献并剔除不符合要求的文献,最终纳入12篇。利用RevMan5.0对各研究结果进行异质性检验和效应值合并计算,选择OR值及其95%CI作为Meta分析指标。若各独立研究结果具有同质性,采用固定效应模型(F),反之则采用随机模型(R),用Stata10.0软件的Begg's检验和Egger's检验分析发表偏倚。结果实验组与对照组相比,等位基因HLA-DRB1*03、HLA-DRB1*08和HLA-DRB1*12是中国人群宫颈癌的保护基因(均P0.05),等位基因HLA-DRB1*10. HLA-DRB1*14.HLA-DRBl*15.HLA-DRBl*0301.HLA-DRB1*0403.HLA-DRB1*0404. HLA-DRB1*0803.HLA-DRB1*1312和HLA-DRB1*1502是中国人群宫颈癌的危险基因(均P0.05)。结论本Meta分析结果表明,HLA-DRB1基因多态性与中国人群宫颈癌的易感性存在一定的关联。
[Abstract]:Objective to investigate the relationship between the polymorphism of human leukocyte antigen-DRB1 gene and the risk of cervical cancer by Meta analysis. Methods by searching the full-text database of Chinese academic journals, (VIP), Wanfang data, PubMed.Elsevier.Springer Link database and oral Cochrane Library database, using the keywords or subject words "cervical cancer" and "alleles", (CNKI), Wafang data, PubMed.Elsevier.Springer Link database and oral Cochrane Library database were used. "genetic polymorphism", "human leukocyte antigen", The 'HLA-DRB' search for Chinese and English literature on the relationship between human leukocyte antigen (HLA-DRB1) gene polymorphism and susceptibility to cervical cancer published in May 2013 from the establishment of databases to the publication of a case-control study on the association of human leukocyte antigen (HLA-DRB1) gene polymorphisms with susceptibility to cervical cancer Comprehensive retrieval of relevant literature and elimination of non-compliant literature, finally included in 12. RevMan5.0 was used to test the heterogeneity of the research results and to combine the effect values. The OR value and its 95%CI were selected as the index of Meta analysis. If the independent research results are homogeneous, the fixed effect model (F), is used instead, the random model (R), is used to analyze the bias of publication with Stata10.0 software Begg's test and Egger's test. Results compared with the control group, the allele HLA-DRB1*03,HLA-DRB1*08 and HLA-DRB1*12 were the protective genes of cervical cancer in Chinese population (P0.05), and the allele HLA-DRB1*10. was the same as that of the control group. HLA-DRB1*14.HLA-DRBl*15.HLA-DRBl*0301.HLA-DRB1*0403.HLA-DRB1*0404. HLA-DRB1*0803.HLA-DRB1*1312 and HLA-DRB1*1502 were risk genes for cervical cancer in Chinese population (P0.05). Conclusion the results of Meta analysis showed that the polymorphism of HLA-DRB1 gene was associated with the susceptibility to cervical cancer in Chinese population.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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