恶性卵巢上皮性肿瘤组织中Gab2蛋白的表达变化及意义

发布时间：2019-04-24 20:13

【摘要】：目的观察恶性卵巢上皮性肿瘤组织中Grb2协同结合蛋白2(Gab2)蛋白的表达变化,并探讨其意义。方法采用免疫组化法对恶性卵巢上皮性肿瘤组织(75例份)、良性卵巢上皮性肿瘤组织(20例份)、正常卵巢组织(20例份)中的Gab2蛋白进行检测。结果恶性卵巢上皮性肿瘤组织、良性卵巢上皮性肿瘤组织Gab2蛋白的阳性表达率分别为61%(46/75)、15%(3/20),正常卵巢组织中3例呈弱阳性(阳性表达率为0);组间Gab2阳性表达率相比,P0.05;恶性卵巢上皮性肿瘤组织Gab2蛋白阳性表达率与良性卵巢上皮性肿瘤组织及正常卵巢组织相比,P均0.05;良性卵巢上皮性肿瘤组织Gab2阳性表达率与正常卵巢组织相比,P0.05。Gab2蛋白阳性表达与恶性卵巢上皮性肿瘤组织学分级、FIGO分期及淋巴结转移相关(P均0.05)。结论 Gab2蛋白在恶性卵巢上皮性肿瘤组织中高表达,其高表达可能预示着该肿瘤侵袭性高、预后差、易复发。
[Abstract]:Objective to investigate the expression and significance of Grb2-binding protein 2 (Gab2) in malignant ovarian epithelial tumors. Methods Immunohistochemistry was used to detect Gab2 protein in malignant ovarian epithelial tumors (75 samples), benign ovarian epithelial tumors (20 cases) and normal ovarian tissues (20 cases). Results the positive rates of Gab2 protein in malignant and benign ovarian epithelial tumors were 61% (46 / 75) and 15% (3 / 20), respectively. The positive expression rate of Gab2 protein in malignant ovarian epithelial tumor was significantly higher than that in benign ovarian epithelial tumor and normal ovarian tissue (P < 0.05), and the positive expression rate of Gab2 protein in malignant ovarian epithelial tumor was significantly higher than that in benign ovarian epithelial tumor and normal ovarian tissue. Compared with normal ovarian tissues, the positive expression of Gab2 protein in benign ovarian epithelial tumors was correlated with histological grade, FIGO stage and lymph node metastasis of malignant ovarian epithelial tumors (all P0.05). The positive expression of P0.05.Gab2 protein was correlated with histological grade, FIGO stage and lymph node metastasis of malignant ovarian epithelial tumors. Conclusion the high expression of Gab2 protein in malignant ovarian epithelial tumor may indicate the high invasiveness, poor prognosis and easy recurrence of the tumor.
【作者单位】：潍坊医学院;潍坊市人民医院;
【分类号】：R737.31

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