贞芪扶正颗粒辅助治疗宫颈癌的临床观察

发布时间：2019-05-07 14:05

【摘要】：目的:观察贞芪扶正颗粒辅助治疗宫颈癌的疗效和安全性。方法:86例宫颈癌患者随机分为对照组(43例)和观察组(43例)。对照组患者于化疗前0.5 h分别静脉滴注盐酸苯海拉明注射液20 mg,盐酸格拉司琼葡萄糖注射液5 mg,西咪替丁注射液20mg,静脉滴注0.5 h后开始化疗:多西他赛注射液40 mg/m~2,d1,d8,静脉滴注;注射用顺铂25 mg/m~2,d1-3,静脉滴注;21 d为1个周期,共4~6个周期。观察组患者在对照组治疗的基础上口服贞芪扶正颗粒5 g,每日2次。观察两组患者的临床疗效,治疗前后T细胞亚群指标[CD3+、CD4+、CD8+、自然杀伤细胞(NK)]、功能状态(KPS)评分,化疗终止情况、终止时间、化疗次数及毒副反应发生情况。结果:观察组患者总缓解率显著高于对照组,观察组化疗终止患者占比显著少于对照组,化疗终止时间显著短于对照组,化疗次数显著多于对照组,胃肠道反应、贫血、血小板降低、白细胞下降发生率均显著低于对照组,差异均有统计学意义(P0.05);两组患者肝功能损伤、肾功能损伤、口腔炎发生率比较,差异均无统计学意义(P0.05)。治疗前,两组患者T细胞亚群指标及KPS评分比较,差异均无统计学意义(P0.05)。治疗后,观察组患者CD3+、CD4+、NK细胞水平均显著高于同组治疗前及对照组,CD8+水平显著低于同组治疗前及对照组;两组患者KPS评分均显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P0.05);对照组患者治疗前后T细胞亚群指标比较,差异均无统计学意义(P0.05)。结论:在常规治疗的基础上,贞芪扶正颗粒可提高宫颈癌患者的疗效,改善机体免疫功能,提高生存质量,降低毒副反应。
[Abstract]:Objective: to observe the efficacy and safety of Zhenqi Fuzheng granule in the treatment of cervical cancer. Methods: 86 cases of cervical cancer were randomly divided into control group (43 cases) and observation group (43 cases). The patients in the control group were given diphenhydramine hydrochloride injection 20 mg, granisetron hydrochloride glucose injection 5 mg, cimetidine injection 20 mg, respectively, 0.5 h before chemotherapy. After intravenous infusion for 0.5 h, chemotherapy was started: 40 mg/m~2,d1,d8, of docetaxel injection was given intravenously; Cisplatin was injected intravenously for 25 mg/m~2,d1-3, 21 days as a cycle, a total of 4 cycles for 6 cycles. The patients in the observation group took Zhenqi Fuzheng granule 5 g twice a day on the basis of treatment in the control group. To observe the clinical efficacy of the two groups, T cell subgroup indexes [CD3, CD4, CD8, natural killer cell (NK)], functional status (KPS) score, chemotherapy termination, termination time, chemotherapy times and side effects before and after treatment. Results: the total remission rate of the observation group was significantly higher than that of the control group. The proportion of patients with chemotherapy termination in the observation group was significantly less than that in the control group, the termination time of chemotherapy was significantly shorter than that in the control group, and the number of chemotherapy was significantly higher than that in the control group. The incidence of platelet reduction and leukopenia was significantly lower than that of the control group (P0.05). There was no significant difference in the incidence of liver function injury, renal function injury and stomatitis between the two groups (P0.05). Before treatment, there was no significant difference in T lymphocyte subsets and KPS scores between the two groups (P0.05). After treatment, the levels of CD3, CD4 and NK cells in the observation group were significantly higher than those in the same group before treatment and in the control group, while the level of CD8 in the observation group was significantly lower than that before treatment and in the control group. The KPS score of the two groups was significantly higher than that of the same group before treatment, and that of the observation group was significantly higher than that of the control group, the difference was statistically significant (P0.05). There was no significant difference in T cell subsets before and after treatment in the control group (P0.05). Conclusion: on the basis of routine treatment, Zhenqi Fuzheng granule can improve the curative effect of cervical cancer patients, improve the immune function of the body, improve the quality of life and reduce the toxic and side effects.
【作者单位】：兰州市妇幼保健院药剂科;兰州市妇幼保健院妇科;兰州市妇幼保健院病理科;
【分类号】：R737.33

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