长方案促排卵过程中血清LH低于正常值时补充LH对助孕结局的影响
发布时间：2019-05-07 15:06
【摘要】：目的探讨在体外受精-胚胎移植(IVF-ET)周期长方案促排卵过程中晚卵泡期血清促黄体生成素(LH)低于正常值时,补充基因重组人黄体生成素(r-hLH)或人绝经期尿促性腺激素(HMG)对IVF-ET助孕结局的影响。方法采用回顾性分析,选择因女方输卵管因素行IVF-ET助孕的患者529例,所有患者均采用标准长方案,单用基因重组促卵泡激素(rFSH)促排卵。根据年龄、晚卵泡期血清LH、是否补充外源性LH将所有患者分成6组:35岁的A组血清LH1.2mU/mL,单用rFSH促排46例,B组血清LH1.2mU/mL,补充r-hLH 52例,C组血清LH1.2mU/mL,补充HMG 257例;≥35岁的D组血清LH1.2mU/mL,单用rFSH促排34例,E组血清LH1.2mU/mL,补充rhLH 41例,F组血清LH1.2mU/mL,补充HMG 99例。结果 35岁的3组患者之间和≥35岁的3组患者之间在年龄、不孕年限、BMI,基础FSH、LH、E2水平,Gn使用天数、Gn用量,HCG日LH、P水平,HCG日内膜厚度及获卵数等方面差异均无统计学意义(均P0.05)。B组及E组rFSH总量分别高于C组及F组,差异有统计学意义(均P0.05);B组及F组E2水平及2PN受精率分别明显高于A组及D组,差异有统计学意义(均P0.05);A、B、C组之间优质胚胎率及妊娠率比较差异无统计学意义(均P0.05);E组优质胚胎率及妊娠率明显高于D组,差异有统计学意义(均P0.05)。结论口服避孕药降调长方案晚卵泡期血LH值1.2mU/mL时,适量添加r-hLH可以改善卵子质量,提高受精率,改善妊娠结局,尤其是明显提高≥35岁患者的临床妊娠率、受精率及优胚率。
[Abstract]:Objective to investigate whether the serum luteinizing hormone (LH) in late follicular phase of in vitro fertilization-embryo transfer (IVF-ET) is lower than normal in the course of ovulation induction by long-term regimen of in vitro fertilization-embryo transfer (IVEF). Effects of recombinant human luteinizing hormone (r-hLH) or human gonadotropin (HMG) on the outcome of IVF-ET assisted pregnancy. Methods A retrospective analysis was conducted in 529 patients who were assisted with IVF-ET due to fallopian tube factors. All patients were treated with standard long-term regimen using recombinant follicle-stimulating hormone (rFSH) alone to induce ovulation. According to age, serum LH, in late follicular phase was supplemented with exogenous LH. All patients were divided into 6 groups: 46 cases of serum LH1.2mU/mL, in group A (35 years old) and 52 cases of serum LH1.2mU/mL, supplemented with r-hLH (group B), and 46 cases of serum LH1.2mU/mL, in group A (35 years old). In group C, serum LH1.2mU/mL, was supplemented with HMG in 257 cases; Serum LH1.2mU/mL, in group D (鈮，
本文编号：2471178
[Abstract]:Objective to investigate whether the serum luteinizing hormone (LH) in late follicular phase of in vitro fertilization-embryo transfer (IVF-ET) is lower than normal in the course of ovulation induction by long-term regimen of in vitro fertilization-embryo transfer (IVEF). Effects of recombinant human luteinizing hormone (r-hLH) or human gonadotropin (HMG) on the outcome of IVF-ET assisted pregnancy. Methods A retrospective analysis was conducted in 529 patients who were assisted with IVF-ET due to fallopian tube factors. All patients were treated with standard long-term regimen using recombinant follicle-stimulating hormone (rFSH) alone to induce ovulation. According to age, serum LH, in late follicular phase was supplemented with exogenous LH. All patients were divided into 6 groups: 46 cases of serum LH1.2mU/mL, in group A (35 years old) and 52 cases of serum LH1.2mU/mL, supplemented with r-hLH (group B), and 46 cases of serum LH1.2mU/mL, in group A (35 years old). In group C, serum LH1.2mU/mL, was supplemented with HMG in 257 cases; Serum LH1.2mU/mL, in group D (鈮，
本文编号：2471178
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