宫腹腔镜结合助孕Ⅱ号治疗输卵管阻塞性不孕的临床研究

发布时间：2019-06-01 07:04

【摘要】：目的：观察研究宫腹腔镜术后口服助孕Ⅱ号方治疗输卵管阻塞性不孕患者的临床疗效。方法：将符合筛选标准的60例患者，采用随机数字法分为治疗组和对照组，每组30例，在进行宫腹腔镜手术后常规抗感染治疗以外，治疗组给予口服助孕Ⅱ号方治疗，对照组采取期待疗法。结果： ①宫内妊娠情况比较：治疗组宫内妊娠12例，对照组宫内妊娠5例，治疗组疗效优于对照组（P＜0.05）； ②未受孕者术后1年输卵管通畅情况比较：治疗组通畅率55.56%，堵塞率30.56%，对照组通畅率26.00%，，堵塞率50.00%，治疗组优于对照组（P＜0.05）； ③治疗前后的症状体征积分情况比较：治疗组治疗前的总积分平均22.80±7.13，治疗后的总积分平均7.77±5.16，对照组治疗前的总积分平均22.40±6.94，治疗后的总积分平均10.93±7.13，两组的治疗都可以缓解患者的临床症状、体征（P＜0.05），但是两组治疗后的总积分经检验无明显差异（P＞0.05）； ④综合疗效情况比较：治疗组30例中治愈12例，显效6例，有效11例，无效1例，总有效率96.67%，对照组30例中治愈5例，显效4例，有效13例，无效8例，总有效率73.33%，治疗组疗效优于对照组（P＜0.05）； ⑤病情严重程度与宫内妊娠情况比较：16例轻度患者中有9例（56.25%）宫内妊娠，33例中度患者中有7例（21.21%）宫内妊娠，11例重度患者中有1例（9.09%）宫内妊娠，病情程度越轻，宫内妊娠率越高（P＜0.05）； ⑥术后妊娠时间比较：治疗组6—12个月内宫内妊娠6例，对照组6—12个月内宫内妊娠1例，治疗组优于对照组（P＜0.05）。结论：宫腹腔镜术后结合助孕Ⅱ号方治疗输卵管阻塞性不孕有一定的临床疗效，没有明显不良反应，可提高患者宫内妊娠率，防止输卵管再粘连的发生。
[Abstract]:Objective: to observe and study the clinical effect of oral Zhiyao No. 2 recipe after hysteroscopy in the treatment of infertile patients with tubal obstruction. Methods: sixty patients who met the screening criteria were randomly divided into treatment group (n = 30) and control group (n = 30). In addition to routine anti-infection treatment after laparoscopic hysteroscopy, the treatment group was treated with oral Zhuyue recipe II. The control group was treated with expectation therapy. Results: 1 comparison of intrauterine pregnancy: there were 12 cases of intrauterine pregnancy in the treatment group and 5 cases in the control group. The curative effect of the treatment group was better than that of the control group (P < 0.05). 2 comparison of tubal patency in patients without pregnancy one year after operation: the patency rate of the treatment group was 55.56%, the blocking rate was 30.56%, the patency rate of the control group was 26.00%, and the blocking rate was 50.00%. The treatment group was superior to the control group (P < 0.05). 3Compared with the scores of symptoms and signs before and after treatment: the average total score was 22.80 卤7.13 in the treatment group, 7.77 卤5.16 in the treatment group and 22.40 卤6.94 in the control group before treatment. The average total score after treatment was 10.93 卤7.13. Both groups could relieve the clinical symptoms and signs (P < 0.05), but there was no significant difference in the total score between the two groups (P > 0.05). 4 comparison of comprehensive curative effects: in the treatment group, 12 cases were cured, 6 cases were markedly effective, 11 cases were effective, 1 case was ineffective, the total effective rate was 96.67%, 5 cases were cured, 4 cases were markedly effective, 13 cases were effective and 8 cases were ineffective in the control group. The total effective rate was 73.33%. The curative effect of the treatment group was better than that of the control group (P < 0.05). (5) the severity of the disease was compared with that of intrauterine pregnancy: among 16 cases of mild pregnancy, 9 cases (56.25%) were pregnant in uterus, 7 cases (21.21%) in 33 cases were moderate, and there were 9 cases (56.25%) in mild cases and 7 cases (21.21%) in 33 cases. In 11 patients with severe pregnancy, 1 case (9.09%) was pregnant in uterus. The lighter the severity of the disease, the higher the rate of intrauterine pregnancy (P < 0.05). 6 comparison of postoperative pregnancy time: 6 cases of intrauterine pregnancy in the treatment group and 1 case in the control group within 6 times 12 months, the treatment group was better than the control group (P < 0.05). Conclusion: hysteroscopy combined with No. 2 prescription has certain clinical effect in the treatment of tubal obstructive sterility, and there is no obvious adverse reaction, which can improve the rate of intrauterine pregnancy and prevent the recurrence of tubal adhesion.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.6

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