337例胎儿超声软指标阳性染色体结果分析
发布时间：2019-06-05 17:29
【摘要】：目的分析337例胎儿超声软指标(USMs)阳性的染色体结果,并探讨其与染色体异常的关系。方法对行产前诊断且USMs阳性的337例孕妇,统计染色体结果行回顾性分析,将研究对象分为单纯USMs阳性组(A组,186例;1项USMs阳性为A1组,150例;2项及以上USMs阳性为A2组,36例),USMs阳性合并高龄或唐筛高风险组(B组,82例),USMs阳性合并其他异常组(C组,69例),并分析其与染色体的联系。结果 A1组、A2组染色体异常发生率比较,差异无统计学意义;A组与B组染色体异常率比较差异无统计学意义;A组与C组异常率比较差异有统计学意义(P0.05)。结论 USMs阳性可能增加染色体异常风险,需正确评估其应用价值以减少不必要的有创产前诊断,但是合并其他结构异常,必须在染色体正常的前提下继续妊娠。
[Abstract]:Objective to analyze the chromosome results of ultrasound soft index (USMs) positive in 337 fetuses and to explore the relationship between them and chromosome abnormalities. Methods the chromosome results of 337 pregnant women diagnosed before delivery and USMs positive were analyzed retrospectively. the subjects were divided into simple USMs positive group (group A, n = 186), 1 USMs positive group (n = 150), and 1 USMs positive group (n = 150). Two or more USMs positive groups were A2, 36), USMs positive patients with advanced age or high risk group (group B, 82), USMs positive patients with other abnormalities (group C, 69 patients), and the relationship with chromosomes was analyzed. Results there was no significant difference in the incidence of chromosome abnormalities between group A1 and group A2, there was no significant difference in the abnormal rate between group A and group B, and there was significant difference between group A and group C (P 0.05). Conclusion USMs positive may increase the risk of chromosome abnormalities. It is necessary to correctly evaluate its application value in order to reduce unnecessary invasive predelivery diagnosis, but with other structural abnormalities, it is necessary to continue pregnancy under the premise of normal chromosomes.
【作者单位】： 安徽医科大学第一附属医院妇产科产前诊断中心;
【基金】：安徽省自然科学基金(编号:1208085MH172) 安徽高校省级自然科学研究项目(编号:KJ2011Z215)
【分类号】：R714.5
[Abstract]:Objective to analyze the chromosome results of ultrasound soft index (USMs) positive in 337 fetuses and to explore the relationship between them and chromosome abnormalities. Methods the chromosome results of 337 pregnant women diagnosed before delivery and USMs positive were analyzed retrospectively. the subjects were divided into simple USMs positive group (group A, n = 186), 1 USMs positive group (n = 150), and 1 USMs positive group (n = 150). Two or more USMs positive groups were A2, 36), USMs positive patients with advanced age or high risk group (group B, 82), USMs positive patients with other abnormalities (group C, 69 patients), and the relationship with chromosomes was analyzed. Results there was no significant difference in the incidence of chromosome abnormalities between group A1 and group A2, there was no significant difference in the abnormal rate between group A and group B, and there was significant difference between group A and group C (P 0.05). Conclusion USMs positive may increase the risk of chromosome abnormalities. It is necessary to correctly evaluate its application value in order to reduce unnecessary invasive predelivery diagnosis, but with other structural abnormalities, it is necessary to continue pregnancy under the premise of normal chromosomes.
【作者单位】： 安徽医科大学第一附属医院妇产科产前诊断中心;
【基金】：安徽省自然科学基金(编号:1208085MH172) 安徽高校省级自然科学研究项目(编号:KJ2011Z215)
【分类号】：R714.5
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