孤立性轻度侧脑室增宽胎儿的产前诊断及预后分析

发布时间：2019-06-11 02:38

【摘要】：目的:研究孤立性轻度侧脑室增宽(i MVM)胎儿与染色体异常、先天性宫内感染及不良妊娠结局的关系。方法:回顾性分析我院2009年1月至2013年12月i MVM胎儿143例的产前诊断情况及妊娠结局。结果:143例i MVM胎儿中共有48例(33.57%)同意产前诊断,行胎儿染色体核型及TORCH-Ig M检查,发现1例(2.08%)染色体异常,为47,XX,+21;2例(4.17%)胎儿分别合并巨细胞病毒和弓形体感染。89例(62.24%)有追踪随访结果,其中1例21-三体终止妊娠,3例孕妇主动选择终止妊娠,2例分别合并继发性耳聋和语言发育障碍,其余83例(93.26%)在出生后0~4年内智力及生长发育正常;在i MVM的胎儿中男女比例为2.07∶1。结论:排除i MVM胎儿的染色体异常及先天性宫内感染后,此类胎儿的预后良好,而且男胎发病率远远高于女胎。
[Abstract]:Objective: to study the relationship between isolated mild widening of lateral ventricle (i MVM) and chromosome abnormality, congenital intrauterine infection and adverse pregnancy outcome. Methods: the antenatal diagnosis and pregnancy outcome of 143 I MVM fetuses in our hospital from January 2009 to December 2013 were analyzed retrospectively. Results: a total of 48 cases (33.57%) of 143 I MVM fetuses agreed to antenatal diagnosis. Fetal karyotype and TORCH-Ig M examination showed that 1 case (2.08%) had chromosome abnormality, which was 47, XX21. Two fetuses (4.17%) were complicated with Cytomegalovirus and Toxoplasma gondii infection, respectively. 89 cases (62.24%) had follow-up results, including 1 case of 21-trisomy termination of pregnancy and 3 cases of pregnant women actively choosing to terminate pregnancy. 2 cases were complicated with secondary deafness and language development disorder, and the other 83 cases (93.26%) had normal intelligence and growth and development within 4 years after birth. The ratio of male to female in I MVM is 2.07%. Conclusion: after excluding chromosome abnormalities and congenital intrauterine infection of I MVM fetuses, the prognosis of this kind of fetuses is good, and the incidence of male fetuses is much higher than that of female fetuses.
【作者单位】：广州医科大学附属第三医院;
【基金】：广东省自然科学基金(编号:S2013040012653) 广州市卫生局基金(编号:20131A011156) 广州医学院博士启动基金(编号:2011C42) 广州医科大学附属第三医院博士启动基金(编号:2012Y18)
【分类号】：R714.53

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