细胞因子信号转导抑制因子3、雌激素受体和宫腔粘连之间关系的研究

发布时间：2019-06-12 17:37

【摘要】：目的：探讨复发性流产患者的粘连组织中细胞因子信号转导抑制因子3（SOCS3）、雌激素受体（ER）和宫腔粘连(IUA)之间关系，并分析其临床意义。方法：采用免疫组化方法分别检测50例复发性流产患者的宫腔粘连组织中SOCS3、ER的表达情况；根据欧洲妇科内镜协会ESGF标准将50例宫腔粘连的复发性流产患者分为I-V度，分析SOCS3、ER和宫腔粘连之间的关系。结果： 1. SOCS3阳性呈棕黄色絮状主要定位于胞浆，宫腔粘连的严重程度和SCOS3在宫腔粘连组织中的表达情况之间存在趋势性（P=0.00030.01），即随着宫腔粘连程度越严重，SOCS3的表达强度越高。 2. ER阳性呈棕褐色颗粒状定位于胞核，胞质中；宫腔粘连的严重程度和ER在宫腔粘连组织中的表达情况之间存在趋势性（P=0.00070.01），即随着宫腔粘连程度越严重，ER的表达强度越高。 3.在宫腔粘连组织中，ER的表达都与SOCS3的表达是一致的（Kappa=0.483，P=0.001）。结论： 1. SOCS3、ER可能在宫腔粘连的发病机制中发挥重要作用，，但SOCS3是否是通过对酪氨酸蛋白激酶/信号传导子和转录激活子信号传导(JAK-STAT)通路的调节作用来引起宫腔粘连的发生，尚待进一步研究。 2. SOCS3、ER可能通过相互作用共同参与了宫腔粘连的形成。
[Abstract]:Objective: To study the relationship between cytokine signal transduction inhibitor 3 (SOCS3), estrogen receptor (ER) and intrauterine adhesion (IUA) in the adhesion tissue of patients with recurrent abortion, and to analyze its clinical significance. Methods: Immunohistochemical method was used to detect the expression of SOCS3 and ER in 50 patients with recurrent spontaneous abortion. 3. The relationship between ER and intrauterine adhesion Department. Results:1. The positive expression of SOCS3 in the cytoplasm, the severity of the adhesion of the uterine cavity and the expression of the SCOS3 in the tissue of the uterine cavity (P = 0.0003.01), that is, the more serious the adhesion of the uterine cavity, the more serious the SOCS3. The higher the intensity of the uterine cavity, the higher the intensity.2. The expression of ER positive in the cytoplasm of the cytoplasm, the severity of the adhesion of the uterine cavity and the expression of ER in the tissue of the uterine cavity (P = 0.0007.01), that is, the more serious the degree of adhesion of the uterine cavity, ER. The higher the expression of ER, the expression of ER was consistent with the expression of SOCS3 (Kappa = 0.483). ,P= 0.001) Conclusion:1. SOCS3, ER may play an important role in the pathogenesis of intrauterine adhesion, but whether SOCS3 is caused by the regulation of tyrosine protein kinase/ signaling and transcriptional activator signaling (JAK-STAT) pathway the occurrence of adhesion has yet to be further studied.2. SOCS3, ER may pass through phase
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.74

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