Sema 3A及其受体在子宫内膜异位症中的表达及意义

发布时间：2019-06-14 04:14

【摘要】：目的检测Sema 3A及其受体在子宫内膜异位症中的表达,探讨Sema 3A及其受体在子宫内膜异位症的发生和发展中的意义。方法收集2013年1月1日至12月31日在中山大学附属第一医院妇科住院并行手术治疗的腹膜子宫内膜异位症(PEM)患者24例、卵巢子宫内膜异位囊肿(OEM)患者24例和结直肠子宫内膜异位症(CREM)患者20例,采用免疫组化SP法检测异位病灶腺上皮细胞中Sema 3A、Plexin A1和NRP-1的表达,并与26例非子宫内膜异位症患者在位内膜(Eu E-NEM)、22例子宫内膜异位症患者在位内膜(Eu E-EM)中的表达进行比较。结果Sema 3A在Eu E-EM组腺上皮细胞中的表达比Eu E-NEM组腺上皮细胞中的表达高(309.09±66.61、207.69±56.02),差异有统计学意义(P0.01)。PEM、OEM、CREM的异位病灶腺上皮细胞之间的Sema 3A、Plexin A1、NRP-1的免疫组织化学HSCORE评分差异均无统计学意义(P0.05)。PEM组、OEM组、CREM组中异位病灶腺上皮细胞中的Sema3A、Plexin A1、NRP-1的表达均比内膜异位症患者组的在位内膜和非内膜异位症患者组的在位内膜腺上皮细胞中的表达高(P值均0.05)。结论 Sema 3A及其受体在不同类型内膜异位症病灶腺上皮细胞中的表达增高,提示其高表达可能参与了子宫内膜异位症的发生发展。
[Abstract]:Objective to detect the expression of Sema 3A and its receptor in Endometriosis and to explore the significance of Sema 3A and its receptor in the occurrence and development of Endometriosis. Methods from January 1 to December 31, 2013, 24 patients with (PEM), 24 patients with ovarian Endometriosis cyst (OEM) and 20 patients with colorectal Endometriosis (CREM) were enrolled in the first affiliated Hospital of Sun Yat-sen University. The expression of Sema 3A, Plexin A1 and NRP-1 in the epithelial cells of ectopic lesions was detected by SP method. The expression of Eu E-EM in 26 cases of non-Endometriosis and 22 cases of Endometriosis was compared with that of 26 cases of non-Endometriosis (Eu E-EM) and 22 cases of Endometriosis. Results the expression of Sema 3A in Eu E-EM group was higher than that in Eu E-NEM group (309.09 卤66.61207.69 卤56.02), the difference was statistically significant (P 0.01). There was no significant difference in Sema 3A, Plexin A1 and NRP 鈮，

本文编号：2499090