ROC曲线评价血浆D-二聚体水平在子痫前期诊断中的价值

发布时间：2019-06-19 03:50

【摘要】：目的评价血浆D-二聚体水平在子痫前期(PE)诊断中的价值。方法选择PE患者88例(重度56例、轻度32例)和正常妊娠妇女43例,检测各组血浆D-二聚体水平以及出凝血相关指标,并分析血浆D-二聚体水平与PE病情程度的关系;同时采用受试者工作特征(ROC)曲线分析法评价血浆D-二聚体水平在PE诊断中的价值。结果与正常妊娠妇女比较,PE患者血浆D-二聚体水平显著升高(P0.05),且重度PE患者血浆D-二聚体水平显著高于轻度PE患者(P0.05)。血浆D-二聚体诊断PE的ROC曲线下面积为0.901。当血浆D-二聚体取值0.685μg/m L时,预测PE的敏感性为96.2%,特异性为71.4%,95%CI为0.729~1.000。相关分析发现,PE患者血浆D-二聚体水平随SBP、DBP水平升高而升高,呈正相关(r分别为0.32、0.33,P0.05)。结论血浆D-二聚体水平与PE病情发展密切相关,是评估PE病情程度的良好指标。
[Abstract]:Objective to evaluate the value of plasma D-dimer level in the diagnosis of preeclampsia (PE). Methods the plasma D-dimer level and coagulation related indexes were measured in 88 patients with PE (56 severe, 32 mild) and 43 normal pregnant women, and the relationship between plasma D-dimer level and the severity of PE was analyzed, and the value of plasma D-dimer level in the diagnosis of PE was evaluated by (ROC) curve analysis. Results compared with normal pregnant women, the level of plasma D-dimer in patients with PE was significantly higher than that in patients with mild PE (P 0.05), and the level of plasma D-dimer in patients with severe PE was significantly higher than that in patients with mild PE (P 0.05). The area under the ROC curve of plasma D-dimer in the diagnosis of PE is 0.901. When the value of plasma D-dimer was 0.685 渭 g / mL, the sensitivity, specificity and 95% CI of predicting PE were 96.2%, 71.4% and 0.729 卤1.000, respectively. Correlation analysis showed that plasma D-dimer level increased with the increase of SBP,DBP level in PE patients, and there was a positive correlation (r = 0.32, 0.33, P 0.05). Conclusion Plasma D-dimer level is closely related to the development of PE and is a good index to evaluate the severity of PE.
【作者单位】：青岛大学医学院;莒县人民医院;菏泽医学专科学校;
【分类号】：R714.244

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