米非司酮与左炔诺孕酮对功能失调性子宫出血患者的疗效与安全性评价

发布时间：2019-06-19 05:54

【摘要】：目的评价左炔诺孕酮宫内缓释给药与米非司酮治疗围绝经期功能失调性子宫出血患者的临床疗效和安全性。方法 106例围绝经期功能失调性子宫出血患者随机分为试验组和对照组,各53例,试验组患者用左炔诺孕酮缓释系统治疗,对照组患者用米非司酮治疗,观察2组患者治疗前后临床疗效、不良反应发生率及对患者子宫内膜厚度、月经量、血红蛋白浓度的影响。结果试验组有效率(94.34%)显著高于对照组(67.92%,P0.05);试验组患者不良反应发生率(7.55%)显著低于对照组(33.96%,P0.05)。治疗后,2组患者子宫内膜厚度、月经量显著降低,血红蛋白浓度显著升高(P0.05),且试验组治疗后上述指标变化更为显著(P0.05)。结论左炔诺孕酮宫内缓释系统治疗围绝经期功能失调性子宫出血疗效显著,不良反应发生率低。
[Abstract]:Objective to evaluate the clinical efficacy and safety of levonorgestrel sustained release administration and mifepristone in the treatment of perioperative dysfunctional uterine bleeding. Methods 106 patients with peri-menopausal dysfunctional uterine bleeding were randomly divided into experimental group (n = 53) and control group (n = 53). The patients in the experimental group were treated with levonorgestrel sustained release system and the patients in the control group were treated with mifepristone. The clinical efficacy, incidence of adverse reactions and the effects on intimal thickness, menstrual volume and hemoglobin concentration were observed before and after treatment. Results the effective rate of the experimental group (94.34%) was significantly higher than that of the control group (67.92%, P 0.05), and the incidence of adverse reactions in the experimental group (7.55%) was significantly lower than that of the control group (33.96%, P 0.05). After treatment, the intimal thickness and menstrual volume of the two groups were significantly decreased, and the hemoglobin concentration was significantly increased (P 0.05), and the changes of the above indexes were more significant after treatment in the experimental group (P 0.05). Conclusion levonorgestrel sustained release system is effective in the treatment of menopausal dysfunctional uterine bleeding, and the incidence of adverse reactions is low.
【作者单位】：宁波市妇女儿童医院药剂科;宁波市妇女儿童医院妇产科;福建医科大学教学医院妇产科;
【基金】：省卫生厅青年基金课题基金资助项目(2009229)
【分类号】：R711.52

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