不同配准方法对宫颈癌靶区器官的形变研究

发布时间：2019-06-21 01:47

【摘要】：目的比较4种基于灰度的配准方法(刚性、仿射、B样条弹性、关注感兴趣区的弹性配准)对宫颈癌靶区器官在不同分次间的形变精度。方法选取30例宫颈癌患者,均分为3组,第1组的每个病例有2套不同分次外照射的CT图像,第2组有2套不同分次后装照射的CT图像,第3组有单次外照射和单次后装照射的CT图像。首先,由同一个医生勾画所有CT图像的GTV、直肠和膀胱,然后每一组分别使用上述4种方法进行配准,接着,在形变图像上勾画GTV、直肠和膀胱,与参考图像上的GTV、直肠和膀胱进行比较,以它们的形变指数(由区域重叠度和轮廓适形指数组成)衡量4种配准方法的配准精度。结果在30例患者中,关注感兴趣区的配准方法(简称ROI方法)的精度高于其他方法,在第1组中占优的数量为直肠9例、膀胱10例、GTV 10例,第2组为直肠8例、膀胱9例、GTV 10例,第3组为直肠9例、膀胱10例、GTV 10例。与刚性配准方法的精度相比,第1组的ROI方法、B样条弹性配准、仿射配准与它的差值分别为11%~64%、-18%~39%、-12%~11%,第2组为4%~56%、-17%~58%、-7%~68%,第3组为10%~76%、-17%~41%、-6%~20%。结论在不同分次放疗宫颈癌的CT图像进行配准时,ROI方法能提高肿瘤靶区、直肠和膀胱的配准精度,有利于准确地获取它们在即往放疗方案的总剂量。
[Abstract]:Objective to compare the deformation accuracy of four registration methods based on gray scale (rigid, affine, B-spline elasticity, elastic registration of region of interest) for cervical cancer target organs in different grades. Methods 30 patients with cervical cancer were divided into three groups. Each case in group 1 had two sets of CT images with different external irradiation, the second group had two sets of CT images with different stages of external irradiation, and the third group had CT images of single external irradiation and single afterirradiation. First, the GTV, rectum and bladder of all CT images were sketched by the same doctor, and then each group was registered with the above four methods respectively. then, the GTV, rectum and bladder were sketched on the deformation image and compared with the GTV, rectum and bladder on the reference image, and the registration accuracy of the four registration methods was measured by their deformation index (composed of regional overlap and conformal index). Results in 30 patients, the accuracy of the registration method of region of interest (ROI) was higher than that of other methods. In group 1, there were 9 cases of rectum, 10 cases of bladder, 10 cases of GTV, 8 cases of rectum, 9 cases of bladder, 10 cases of GTV, 9 cases of rectum, 10 cases of bladder and 10 cases of GTV in group 3. Compared with the accuracy of rigid registration method, the difference between group 1 ROI method, B-spline elastic registration, affine registration and rigid registration is 11% 64%, 18% 39%, 12% 11%, 4% 56%, 17% 58%, 7% 68%, 10% 76%, 17% 41%, 6% 20%, respectively. the difference between affine registration and rigid registration is 11% 64%, 18% 39%, 12% 11%, 4% 56%, 17% 58%, 7% 68%, 10% 76%, 17% 41%, 6% 20%, respectively. Conclusion ROI can improve the registration accuracy of tumor target, rectum and bladder, and is helpful to obtain the total dose of radiotherapy regimen in different stages of radiotherapy for cervical cancer.
【作者单位】： 广州医科大学附属肿瘤医院放疗中心;广州医科大学附属肿瘤医院放射科;
【基金】：广东省教育厅特色创新项目(自然科学类)(编号:2014KTSCX104) 广州市医药卫生科技一般引导项目(编号:20151A011085)
【分类号】：R737.33;TP391.41
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本文编号：2503689