TRAF6在卵巢癌组织中的表达及临床意义

发布时间：2019-06-21 00:19

【摘要】：目的:探讨肿瘤坏死因子受体相关因子6(TRAF6)在卵巢癌及癌旁正常卵巢组织中的表达与临床意义。方法:收集2001年8月至2009年12月在我院接受手术治疗的102例卵巢癌患者的肿瘤标本及相对应的癌旁正常卵巢组织标本,所有肿瘤组织均经术后病理学检测结果证实,通过免疫组织化学方法检测TRAF6蛋白在卵巢癌及癌旁正常组织中的表达,并探讨TRAF6的表达量与临床病理特征和预后的相关性。结果:卵巢癌组织中TRAF6的阳性表达率为68.6%,显著高于癌旁正常卵巢组织中的20.5%(P0.05);进一步研究发现,TRAF6的表达量与卵巢癌患者的年龄、肿瘤大小、有无腹水、组织学类型和病理分级无关(P0.05),与患者有无淋巴结转移及临床分期相关(P0.05);TRAF6阳性表达的患者五年生存率显著低于阴性表达的患者(P0.001)。结论:TRAF6在卵巢癌组织中的表达显著降低,其可能在卵巢癌的发生、发展和侵袭中发挥重要作用。
[Abstract]:Objective: to investigate the expression and clinical significance of tumor necrosis factor receptor related factor 6 (TRAF6) in ovarian cancer and adjacent normal ovarian tissues. Methods: from August 2001 to December 2009, the tumor specimens of 102 patients with ovarian cancer and the corresponding normal ovarian tissues adjacent to cancer were collected. The expression of TRAF6 protein in ovarian cancer and adjacent normal tissues was detected by immunohistochemistry, and the correlation between the expression of TRAF6 and clinicopathological features and prognosis was discussed. Results: the positive expression rate of TRAF6 in ovarian cancer tissues was 68.6%, which was significantly higher than that in normal ovarian tissues adjacent to ovarian cancer (20.5%). Further study showed that the expression of TRAF6 was not related to the age, tumor size, ascitic fluid, histology type and pathological grade of ovarian cancer patients (P 0.05), but correlated with lymph node metastasis and clinical stage (P 0.05). The 5-year survival rate of patients with positive expression of TRAF6 was significantly lower than that of patients with negative expression (P0.001). Conclusion: the expression of TRAF6 in ovarian cancer is significantly decreased, which may play an important role in the occurrence, development and invasion of ovarian cancer.
【作者单位】：湖北民族学院附属民大医院产科;
【分类号】：R737.31

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