妊娠糖尿病患者的睡眠持续时间与其血糖控制情况间的相关性研究

发布时间：2019-06-21 09:20

【摘要】：目的研究妊娠糖尿病(GDM)患者的睡眠状况与其血糖控制情况间的关系。方法将临床新近诊断为GDM,且未开始进行胰岛素或格列本脲治疗的孕产妇纳入研究。指导所有患者正确使用血糖仪及遵循GDM饮食原则。所有患者连续7d记录睡眠日志,包括上床时间和觉醒时间。使用线性混合模型分析GDM患者睡眠持续时间与其清晨空腹血糖及餐后1h血糖浓度间的关系。结果最终收集65例连续7d完整的睡眠记录表和血糖检测值。睡眠时间缩短与空腹和餐后1h血糖浓度呈显著负相关。在调整年龄、孕龄和体质量指数后,睡眠持续时间每增加1h则空腹血糖明显下降,二者呈显著相关[-2.13mg/dL,95%CI(-3.98,-0.20)],与此同时,餐后血糖浓度也明显下降,同样呈显著相关[午餐-4.52mg/dL,95%CI(-8.75,-0.50)vs.晚餐-5.87 mg/dL,95%CI(-9.40,-2.73)]。结论 GDM患者的睡眠持续时间缩短与血糖控制不佳密切相关。告知GDM患者充足睡眠的重要性的同时及早发现和治疗存在睡眠障的患者可以优化其血糖控制水平。
[Abstract]:Objective To study the relationship between sleep and blood glucose control in patients with gestational diabetes mellitus (GDM). Methods The newly diagnosed GDM was newly diagnosed and the pregnant and pregnant women who had not started the treatment of insulin or GDM were included in the study. Instruct all patients to use the meter correctly and follow the GDM diet principle. All patients recorded a sleep log for 7 days, including the time of bed and the time of the wake-up. A linear mixed model was used to analyze the relationship between the sleep duration of the GDM and the fasting blood glucose in the early morning and the glucose concentration of 1 h after the meal. As a result,65 consecutive 7-day complete sleep and blood glucose values were collected. There was a significant negative correlation between the time of sleep and the fasting and postprandial blood glucose concentration. After the age, gestational age, and body mass index were adjusted, the fasting blood glucose was significantly reduced for each increase of 1 hour, both in a significant correlation[-2.13 mg/ dL,95% CI (-3.98,-0.20)], at the same time, the postprandial blood glucose concentration also decreased significantly and also significantly correlated[Lunch-4.52 mg/ dL,95% CI (-8.75, -0.50)vs.鏅氶-5.87 mg/dL,95%CI(-9.40,-2.73)]. Conclusion The shortening of sleep duration in GDM patients is closely related to the poor blood glucose control. To inform GDM patients of the importance of adequate sleep, early detection and treatment of patients with a sleep barrier can optimize their blood glucose control levels.
【作者单位】：四川省成都市双流区中医医院妇产科;四川大学华西第二医院产科;
【基金】：四川省成都市惠民工程项目(2013惠民工程-6)
【分类号】：R714.256

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