精液参数和来源对ICSI助孕患者胚胎质量及临床结局的影响

发布时间：2019-07-01 20:48

【摘要】：目的:分析精子因素对卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)临床结局的影响。方法:回顾性分析不同来源和参数精液行ICSI助孕的临床资料,A组为因精卵结合障碍重复周期行ICSI授精者228周期,B组少弱精子组790周期,C组为附睾穿刺取精(percutaneous epididymal sperm aspiration,PESA)/睾丸穿刺取精(testicular sperm aspiration,TESA)组225周期,比较各组患者行ICSI助孕的胚胎质量及临床结局。结果:3组患者的正常受精率和卵裂率均无统计学差异,A组患者可利用胚胎率明显低于B组,A组患者的优质胚胎率明显低于B、C 2组;新鲜移植周期中A组患者胚胎种植率明显低于B、C2组,临床妊娠率、多胎率、早期流产率、早产率、活产率及新生儿男女性别比例均无显著差异(P0.05),A组患者新生儿体质量高于B、C 2组,且B组高于C组;复苏移植周期A组患者临床妊娠率和胚胎种植率明显低于B、C 2组,且C组大于B组,C组活产率明显大于A、B 2组(P0.05),其他临床指标无统计学差异(P0.05)。结论:精子的参数及来源不影响ICSI治疗的受精、卵裂及早期妊娠;ICSI能够改善受精障碍组的受精情况(A组),但胚胎的质量和发育潜能较低;PESA/TESA组有相对较高的临床妊娠率和种植率。
[Abstract]:Objective: to analyze the effect of sperm factors on the clinical outcome of intracytoplasmic sperm injection of (intracytoplasmic sperm injection,ICSI. Methods: the clinical data of ICSI assisted pregnancy with semen from different sources and parameters were analyzed retrospectively. the embryo quality and clinical outcome of ICSI assisted pregnancy in group A were compared with those in group B (oligozoospermia group), group B (oligozoospermia group) and group C (epididymal puncture / testicular sperm extraction (testicular sperm aspiration,TESA). Results: there was no significant difference in normal fertilizing rate and cleavage rate among the three groups. The available embryo rate in group A was significantly lower than that in group B, and the rate of high quality embryo in group A was significantly lower than that in group B. In the fresh transplantation cycle, the embryo implantation rate of group A was significantly lower than that of group B. there were no significant differences in clinical pregnancy rate, multiple births rate, early abortion rate, premature delivery rate, live delivery rate and sex ratio of newborn between male and female in group C (P 0.05). The body mass of neonates in group), A was higher than that in group B, and group B was higher than group C. The clinical pregnancy rate and embryo implantation rate in group A were significantly lower than those in group B, group C was higher than group B, and the live birth rate in group C was significantly higher than that in group A. there was no significant difference in other clinical indexes between group A and group B (P 0.05). Conclusion: the parameters and sources of spermatozoa do not affect the fertilization, cleavage and early pregnancy treated with ICSI. ICSI can improve the fertilization in group A (group A), but the quality and developmental potential of embryos are low, and the clinical pregnancy rate and implantation rate in PESA/TESA group are relatively high.
【作者单位】：郑州大学第三附属医院生殖中心;
【分类号】：R714.8

【相似文献】