体外受精-胚胎移植中口服避孕药对非排卵障碍患者治疗的影响

发布时间：2019-07-02 09:35

【摘要】：目的研究短效口服避孕药(OCP)对正常卵巢功能的非排卵障碍患者行短效促性腺激素释放激素激动剂(GnRHa)长方案超促排卵治疗及妊娠结局的影响。方法回顾性分析接受体外受精-胚胎移植(IVF-ET)治疗的卵巢功能正常的非排卵障碍不孕症患者130例,按照是否采用OCP分为观察组84例和对照组46例。比较两组治疗指标和妊娠结局。结果两组女方年龄、男方年龄、女方体质量指数(BMI)及不孕年限差异无统计学意义(P0.05);两组患者的Gn使用总量、天数、获卵数以及可移植胚胎数相比差异均无统计学意义(P0.05),正常受精率两组比较差异有统计学意义(P0.05);两组妊娠率差异无统计学意义(P0.05),双胎率在对照组明显升高(P0.05),对照组的着床率高于观察组(P0.05)。两组中均无中重度卵巢过度刺激(OHSS)发生,轻度OHSS发生率观察组较低,但差异无统计学意义(P0.05)。结论非排卵障碍患者的GnRH-a长方案中添加OCP预处理对治疗结局并无明显益处。
[Abstract]:Objective to study the effect of short oral contraceptive (OCP) on superovulatory therapy and pregnancy outcome in patients with normal ovarian dysfunction treated with short effect gonadotropin releasing hormone agonist (GnRHa). Methods 130 infertile patients with normal ovarian dysfunction treated with in vitro fertilisation and embryo transfer (IVF-ET) were divided into observation group (n = 84) and control group (n = 46) according to whether or not OCP was used. The treatment indexes and pregnancy outcome were compared between the two groups. Results there was no significant difference in female age, male age, female body mass index (BMI) and infertile years between the two groups (P 0.05), but there was no significant difference in the total use of Gn, days, number of eggs and number of transferable embryos between the two groups (P 0.05), and there was significant difference in the normal fertilizing rate between the two groups (P 0.05). There was no significant difference in pregnancy rate between the two groups (P 0.05). The twin rate was significantly higher in the control group (P 0.05), and the implantation rate in the control group was higher than that in the observation group (P 0.05). There was no moderate and severe ovarian overstimulation (OHSS) in both groups, but the incidence of mild OHSS was lower in the observation group, but there was no significant difference between the two groups (P 0.05). Conclusion the addition of OCP pretreatment to the long GnRH-a regimen of patients with non-ovulatory disorder has no significant benefit on the outcome of the treatment.
【作者单位】：郑州大学附属洛阳中心医院生殖医学科;
【基金】：河南省洛阳市科技发展项目(1502058B)
【分类号】：R714.8

【相似文献】