乙肝病毒携带对不同卵巢储备功能女性体外受精-胚胎移植结局的影响

发布时间：2019-07-02 09:49

【摘要】：目的探讨乙肝病毒携带对不同卵巢储备功能女性进行体外受精-胚胎移植(IVF-ET)助孕胚胎发育及妊娠结局的影响。方法回顾性分析接受IVF-ET助孕的1 310例不孕症患者资料,按照血清抗苗勒管激素(AMH)水平,分为三组:卵巢储备低下组(A组)AMH2μg/L,正常卵巢储备组(B组)AMH 2~7μg/L,卵巢高储备组(C组)AMH7μg/L,每组按HBs Ag检测结果分为女方乙肝病毒携带组和正常对照组,比较两组的正常受精率、卵裂率、优质胚胎率、着床率、临床妊娠率及流产率有无差异。结果 A组及C组中,乙肝病毒携带组与正常对照组的正常受精率、卵裂率、优质胚胎率、着床率及临床妊娠率差异无统计学意义(P0.05),但A组中乙肝病毒携带组的无可移植胚胎率(14.6%)高于正常对照组(5.9%)(P0.05);B组中乙肝病毒携带组的正常受精率(69.8%)、卵裂率(96.97%)、优质胚胎率(21.8%)、着床率(31.3%)及临床妊娠率(44.1%)均低于正常对照组(73.6%,98.6%,26.2%,41.3%,59.8%)(P0.05),差异有统计学意义。3组中乙肝病毒携带组的流产率均高于正常对照组(P0.05),差异有统计学意义。结论乙肝病毒携带可能干扰了卵巢储备低下及正常卵巢储备女性的卵子质量及胚胎的发育,最终影响妊娠结局。
[Abstract]:Objective to investigate the effect of hepatitis B virus carrier on the development and outcome of in vitro fertilizing and embryo transfer (IVF-ET) assisted pregnancy in women with different ovarian reserve functions. Methods the data of 1 310 infertile patients receiving IVF-ET assisted pregnancy were analyzed retrospectively. according to the level of serum anti-Muller tube hormone (AMH), they were divided into three groups: low ovarian reserve group (group A), normal ovarian reserve group (group B) AMH2 ~ 7 渭 g / L, ovarian high reserve group (group C) AMH 7 渭 g / L. According to the results of HBs Ag test, each group was divided into female hepatitis B virus carrier group and normal control group. There were no differences in cleavage rate, high quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate. Results there was no significant difference in normal fertilizing rate, cleavage rate, high quality embryo rate, implantation rate and clinical pregnancy rate between group A and group C, but the rate of untransplantable embryo in group A (14.6%) was higher than that in normal control group (5.9%) (P 0.05). The normal fertilizing rate (69.8%), cleavage rate (96.97%), high quality embryo rate (21.8%), implantation rate (31.3%) and clinical pregnancy rate (44.1%) in group B were lower than those in normal control group (73.6%, 98.6%, 41.3%, 59.3%, P 0.05). The abortion rate of hepatitis B virus carrier group was higher than that of normal control group (P 0.05), and the difference was statistically significant. Conclusion Hepatitis B virus carrier may interfere with egg quality and embryo development in women with low ovarian reserve and normal ovarian reserve, and finally affect pregnancy outcome.
【作者单位】：厦门市妇幼保健院;
【基金】：福建省科技计划项目(2015D018)~~
【分类号】：R714.8

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