东营市HPV流行和致病情况研究指导预防性疫苗开发和引进

发布时间：2019-07-02 17:00

【摘要】：目的通过检测和统计东营市HPV各亚型在健康人群和宫颈疾病患者中的流行情况,指导当地HPV预防性疫苗的开发和引进。方法留取健康体检妇女以及各级宫颈上皮不典型增生和宫颈癌患者的宫颈脱落细胞,采用基因导流杂交技术检测21种HPV亚型,统计HPV各亚型在健康人群和宫颈疾病患者中的流行情况,分析当地开发和引进预防性HPV疫苗时所应重点选择的亚型。结果在6 401例健康体检人群中,HPV总感染率为15.11%(967/6 401),检出HPV 1 145株,各HPV亚型感染所占比例排名靠前依次为16型(23.23%)、52型(16.68%)、58型(10.22%)、53型(9.34%)、33型(6.29%)、18型(5.94%);在166例HPV感染的CINⅠ~Ⅱ患者中检出HPV亚型198株,各HPV亚型感染所占比例排名靠前依次为16型(18.37%)、58型(14.29%)、31型(14.29%)、52(10.20%)、18型(9.18%)、68型(8.16%);在31例HPV感染的≥CINⅢ患者中检出HPV亚型38株,各HPV亚型感染所占比例排名靠前依次为16型(36.84%)、31型(18.42%)、58型(15.79%)、18型(10.52%)、68型(7.89%)、33型(5.26%)。结论因HPV亚型的流行存在地域性,且各亚型的致病能力不同,所以各地区应综合考虑以上两方面因素,有针对性地开发和引进HPV疫苗。就东营市而言,如果以全面降低人群HPV感染为主要目的,应考虑开发和引进以16、52、58和53型为主的HPV四联预防性疫苗,可降低59.47%的HPV人群感染;如果以降低宫颈癌变为主要目的,应考虑开发和引进以16、31、58和18型为主的HPV四联预防性疫苗,可降低81.57%CINⅢ以上宫颈病变的发生。
[Abstract]:Objective to detect and count the prevalence of HPV subtypes in healthy people and patients with cervical diseases in Dongying City, and to guide the development and introduction of local HPV prophylactic vaccine. Methods the cervical exfoliated cells of healthy women and patients with cervical epithelial atypical hyperplasia and cervical cancer were collected and 21 HPV subtypes were detected by gene diversion hybridom. the prevalence of HPV subtypes in healthy people and patients with cervical diseases was counted, and the subtypes that should be selected in the local development and introduction of prophylactic HPV vaccine were analyzed. Results among 6401 healthy people, the total infection rate of HPV was 15.11% (967 鈮，

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