原发性子宫颈小细胞癌18例临床病理观察
发布时间：2019-07-02 21:24
【摘要】：目的探讨原发性子宫颈小细胞癌(small cell carcinoma of the cervix,SCCC)的临床病理学特征、免疫表型及预后。方法采用免疫组化SP法和原位杂交法对18例SCCC进行临床病理学观察,并结合文献复习。结果 18例SCCC患者年龄30~69岁,平均40岁。SCCC患者临床表现均为阴道不规则出血。妇科检查:子宫颈肿块或子宫颈糜烂。组织学特征:SCCC肿瘤细胞小而一致,可呈圆形似淋巴细胞,但较淋巴细胞大,或呈雀麦形,或部分呈短梭形,细胞质少,境界不清,核染色质呈细颗粒状,深染,核仁不明显,核分裂象多见。免疫表型:肿瘤细胞通常表达CKpan,并不同程度地表达Syn、NSE、Cg A、CD56和p16。原位杂交:检测4例肿瘤细胞HPV 16/18阳性。超微结构:肿瘤细胞内可见神经内分泌颗粒。随访10例SCCC,6例患者2年内死亡。结论 SCCC属神经内分泌癌,是子宫颈少见的高度恶性肿瘤,预后差,其发生可能与HPV 16/18感染有关。CKpan、Syn、Cg A、NSE和CD56是SCCC的免疫标志物,有利于辅助诊断。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotypes and prognosis of primary cervical small cell carcinoma (small cell carcinoma of the cervix,SCCC). Methods Immunohistochemical SP method and in situ hybrid method were used to observe the clinicopathology of 18 cases of SCCC, and the literature was reviewed. Results 18 patients with SCCC were 30 years old and 69 years old, with an average of 40 years old. The clinical manifestations of 18 patients with SCCC were irregular vaginal bleeding. Gynecological examination: cervical mass or cervical erosion. Histologic characteristics: SCCC tumor cells are small and consistent, can be round like lymphocytes, but larger than lymphocytes, or in the shape of Bromus, or part of them are short fusiform, less cellular quality, unclear boundary, nuclear chromatin is fine grain, deep staining, nucleolus is not obvious, mitosis is more common. Immunophenotypic: tumor cells usually express CKpan, and Syn,NSE,Cg A, CD56 and p16. In situ hybridization: the positive rate of HPV 16 鈮，
本文编号：2509248
[Abstract]:Objective to investigate the clinicopathological features, immunophenotypes and prognosis of primary cervical small cell carcinoma (small cell carcinoma of the cervix,SCCC). Methods Immunohistochemical SP method and in situ hybrid method were used to observe the clinicopathology of 18 cases of SCCC, and the literature was reviewed. Results 18 patients with SCCC were 30 years old and 69 years old, with an average of 40 years old. The clinical manifestations of 18 patients with SCCC were irregular vaginal bleeding. Gynecological examination: cervical mass or cervical erosion. Histologic characteristics: SCCC tumor cells are small and consistent, can be round like lymphocytes, but larger than lymphocytes, or in the shape of Bromus, or part of them are short fusiform, less cellular quality, unclear boundary, nuclear chromatin is fine grain, deep staining, nucleolus is not obvious, mitosis is more common. Immunophenotypic: tumor cells usually express CKpan, and Syn,NSE,Cg A, CD56 and p16. In situ hybridization: the positive rate of HPV 16 鈮，
本文编号：2509248
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